氯氰菊酯对大鼠肝线粒体、微粒体钙离子转运的影响  

Effect of Cypermethrin on Calcium Transport in Rat Liver Mitochondria and Microsome

作　　者：夹访贤[1] 张秀莲[1] 于丽华[1] 

机构地区：[1]山东医科大学核医学教研室

出　　处：《中国公共卫生学报》1994年第5期257-259,共3页

摘　　要：采用放射性同位素４５Ｃａ体外测定技术，观察了除虫菊酯类农药氯氰菊酯对大鼠肝线粒体、微粒体Ｃａ２＋转运的影响。结果表明，氯氰菊酯能明显降低大鼠肝线粒体、微粒体对４５Ｃａ主动摄取的能力，且具有明显的剂量一效应关系。同时，它还能显著增加４５Ｃａ从线粒体和微粒体内被动流出，也具有明显的剂量一效应关系和时间一效应关系。Radioactive isotope technique in vitro was used in this paper to observe the effect of Cypermethrin on Calcium transport by rat liver mitochondria and microsome. The result indicated that the activity of the Calcium uptake by mitochondria and microsome was inhibited (P<0. 01 compared with control group) and there was dose-effect relation. At the same time,it can increase significantly the Calcium release from mitochondria and microsome, and there was also dose-effect relation and time-effect relation.

关 键 词：氯氰菊酯 线粒体 微粒体 钙离子 

分 类 号：R139.3[医药卫生—劳动卫生]