低浓度CO对作业工人乳酸脱氢酶及同工酶谱的影响  

Effect of Low Concentration Carbon Monoxide on Serum Lactate Dehydrogenase Isozyme Changes

作　　者：涂荔卿[1] 张文昌[1] 连祥霖[1] 方志红[2] 

机构地区：[1]福建医学院劳动卫生学教研室 [2]福建医学院临床生化教研室

出　　处：《中国公共卫生学报》1994年第6期344-346,共3页

摘　　要：通过对ＣＯ男性作业工人及配对对照的血清ＬＤＨ同工酶的观察，探讨低浓度ＣＯ对血清ＬＤＨ活性和同工酶谱的影响。结果表明：低浓度ＣＯ作业工人血清ＬＤＨＨ亚单位含量降低，Ｍ亚单位含量增高，与对照差异显著（Ｐ＜０．０５）；ＬＤＨ＿２显著低于对照（Ｐ＜０．０５），且ＬＤＨ＿１／ＬＤＨ＿２有增高趋势。两组工人血清ＬＤＨ活性未见显著差异。提示：接触低浓度ＣＯ导致作业工人血清ＬＤＨ同工酶谱发生改变。The Serum Lactate Dehydrogenase (LDH ) and LDH isozyme pattern of 55 male workers who exposed to Carbon Monoxide (CO) and paired-controls were studied, in order todemonstrate the effects of low concentration CO to serumLDH activity and isozyme gram.The results showed: the 76. 75, 12. 82mg/m 3 CO-exposedgroup the serum LDH isozyme H subunit composition decreased and M subunit composition increased, which had asignificant different compared with paired-controls (p<0. 05 ).Futher isozyme analysis showed: in 76. 75mg/m3 CO-exposedgroup the serum LDH2 decreased significantly compared withpaired-controls (p<0. 05). There is a increased tendency inserum LDH1/LDH2 in this group. There were not seen thesignificant different of serum LDH activity between exposureand no-exposure group. Low concentration CO induce serumLDH isozyme pattern changes in exposed workers. It'S worthyby paying attention to the effects of CO to heart emergemetabolism and heart injury.

关 键 词：CO LDH同工酶 心肌损害 

分 类 号：R135.14[医药卫生—劳动卫生]