溴氰菊酯对大鼠肝脏钙稳态影响的体外实验研究  

Effert of Decamethrin on Calcium Homeostasis of Rat Liver in Vitro

作　　者：张秀莲[1] 夹访贤[1] 于丽华[1] 管向东 

机构地区：[1]山东医科大学毒理学研究室

出　　处：《中国公共卫生学报》1994年第6期335-337,共3页

摘　　要：采用体外测定方法，研究了溴氰菊酯对雄性ＳＤ大鼠肝线粒体、微粒体钙稳态的影响。结果表明，溴氰菊酯能明显抑制大鼠肝线粒体、微粒体Ｃａ２＋－ＡＴＰ酶的活力；显著降低大鼠肝线粒体、微粒体对４５Ｃａ主动摄取的能力；并显著增加４５Ｃａ从线粒体、微粒体内的被动流出，三者与对照组相比差异均有显著性意义（Ｐ＜０．０５或Ｐ＜０．０１），都存在明显的剂量、效应关系．Radioactive isotope technique was used in this paper to observe the effect of Decamethrin on Ca transport by rat live mitochondria and microsome. The result indicated that the activity of C4-ATPase was inhibited(P<0. 05 or 0. 01 compared with control)and dose-effect relation was existed. Decamethrin could also decreased the ability of Ca-45 uptake by mitochondria and microsome. The release kinetics indicated that Decamethrin could increase Ca-45 release from mitochondria and microsome and dose-effect relation was also existed.

关 键 词：溴氰菊酯 线粒体 微粒体 农药中毒 肝 钙 

分 类 号：R595.402[医药卫生—内科学]