冬虫夏草醇提取液对实验性急性病毒性心肌炎的影响  

Effect of Cordyceps sinensis alcohol extraction on acute viral myocarditis

作　　者：朱照静[1] 李峰[2] 饶邦复[2] 

机构地区：[1]重庆医科大学药学系 [2]重庆医科大学附属第一医院,重庆400016

出　　处：《中药药理与临床》2005年第1期22-24,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金项目 39870 955

摘　　要：目的:探讨冬虫夏草醇提取物对急性病毒性心肌炎的干预作用。方法:采用柯萨奇B组3型病毒复制病毒性心肌炎小鼠模型,免疫组化染色观察心肌iNOS表达,同时观察光镜下心肌组织学变化。结果:与模型组比较,虫草醇提取物干预组心肌炎症坏死半定量分析显著减轻,心肌iNOS面密度值均显著升高。结论:虫草醇提取物对急性病毒性心肌炎有明显保护作用,其保护机制与诱导心肌iNOS表达,增加NO产生等有关。Objective: To investigated the effect of cordyceps sinensis alcohol extraction (CASE) on acute viral myocarditis (VMC). Methods: Acute VMC model was made in mice with Coxsackievirus B3(CVB3)intraperitoneal inoculation. iNOS in heart was examined immuno-chemically. Histological changes were determined microscopically. Results: Myocardial necrosis semi quantity score were significantly lower(P<0.01)for CASE intervention group, and iNOS density in heart were significantly higher(P<0.01). Conclusions: CSAE has significant protection on acute VMC, and its possible mechanisms include induction of expression of iNOS in heart and increase of NO production.

关 键 词：急性病毒性心肌炎 醇提取液 病毒性心肌炎小鼠模型 实验性 冬虫夏草醇提取物 INOS表达 柯萨奇B组 组织学变化 半定量分析 病毒复制 干预作用 染色观察 免疫组化 炎症坏死 保护作用 保护机制 密度值 虫草 

分 类 号：R285.5[医药卫生—中药学]