消癖颗粒对大鼠乳腺增生模型的影响  

The effects of Xiaopi Granules (消癖颗粒) on the mastoplasia model of rats

作　　者：孟宪波[1] 首弟武[1] 陈立峰[1] 

机构地区：[1]湖南省中医药研究院,长沙410006

出　　处：《中药药理与临床》2005年第1期34-35,共2页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:研究消癖颗粒对大鼠乳腺增生模型的影响。方法:肌肉注射苯甲酸雌二醇和黄体酮诱导大鼠乳腺增生模型;放射免疫法测血清雌二醇、孕酮、促卵泡激素和促黄体生成素的含量;锥板法测血液黏度;组织病理学方法测乳腺小叶数、腺泡数、腺泡腔平均直径、乳腺胞浆面积。结果:消癖颗粒能明显降低乳腺增生大鼠血清雌二醇和促黄体生成素含量,升高孕酮含量;降低全血比黏度;明显减少乳腺小叶数、腺泡数,降低腺泡腔直径,对胞浆面积无明显影响。结论:消癖颗粒对乳腺增生大鼠血清雌激素、血液黏度和乳腺组织病理变化有明显改善作用。Objective: To study the effects of Xiaopi Granules on the mastoplasia model of rats. Methods: The model was established by injecting estradiol benzoate and progesterone. The contents of serum E 2、P、FSH and LH were determined; The hemorrheology and the changes of histological structure of the mammary glands were examined. Results: Xiaopi Granules significantly decreased the levels of serum E 2 and LH, while P significantly increased; significantly decreased blood specific viscosity, the number of acinus and lobule of mammary glands and acinus diameter. Conclusion: Xiaopi Granules significantly improves sex hormone level, hemorrheology and histological structure of the mammary glands of the mastoplasia rats.

关 键 词：乳腺增生模型 颗粒 促黄体生成素 组织病理学方法 血清雌二醇 苯甲酸雌二醇 组织病理变化 血液黏度 乳腺小叶 放射免疫法 促卵泡激素 全血比黏度 血清雌激素 诱导大鼠 肌肉注射 平均直径 孕酮含量 改善作用 浆面积 腺泡 

分 类 号：R285.5[医药卫生—中药学] R944.5[医药卫生—中医学]