复方无名异冲剂对老年大白鼠股骨抗弯力影响的实验研究  

Experimental study on the influence of anti-bending force of the femur of senile rats with Fu Fang Wu Ming Yi Chong Ji

作　　者：刘献祥[1] 俞能宝[1] 董忠 

机构地区：[1]福建中医学院骨研所

出　　处：《中国骨伤》1994年第5期10-11,共2页China Journal of Orthopaedics and Traumatology

摘　　要：采用１２月龄老年大白鼠３２只，随机分为四组，每组８只，用药组喂服无名异冲剂拌混饲料，对照组喂服一般饲料，１８月龄时处死，检测股骨中段弯曲破坏载荷及股骨皮质厚度。结果显示：雄性、雌性大白鼠用药组弯曲破坏载荷，平均骨皮质厚度明显高于对照组（＜０．０５～０．０１）；用药组、对照组雄性大白鼠弯曲破坏载荷明显高于雌性大白鼠（Ｐ＜０．０１）．表明：无名异冲剂具有预防和延缓骨质疏松的发生和发展作用；相同月龄中，雌性大白鼠骨质丧失相对地较雄性大白鼠明显。Thirty-two twelve months old senile rats were divided randomly into four groups with eight in each group.Subjects in the experimental group were feeded with food and Fu Fang Wu Ming Yi Chong Ji (pyrolusite diluent,Chong Ji).The subjects in control group were feeded with food only.All of them were sacrified at 18-month old.Bending destroyed load and thickness of femoral cortex were measured.The results indicated that the bending destroyed load of both sex of the rats and average cortex thickness were prominently higher than the control group(p<0.05-0.01).In both experimental and control group,the bending destroyed load of male rats was prominently higher than that of female one's(p<0.01).This indicates that Chong Ji bears the action of prevention and delaying onset and developing of osteopo-rosis.In the same age group,bone loss of female rats are relatively evidently than that of male ones.

关 键 词：复方无名异冲剂 生物力学 药理学 骨质疏松 股骨 

分 类 号：R285.5[医药卫生—中药学]