实验性汞中毒时肾组织和尿中碱性磷酸酶活性的变化  

Experimental Study on Changes of ALP Activity in Kidney and Urine of Mercury Poisoning Rats

作　　者：郭卫星[1] 王翔朴[1] 

机构地区：[1]湖南医科大学环境医学研究室

出　　处：《卫生毒理学杂志》1989年第1期11-14,共4页Journal of Health Toxicology

基　　金：国家自然科学基金

摘　　要：本研究采用亚急性汞中毒肾损害的大鼠模型,探讨了汞中毒时血、肾和尿中碱性磷酸酶(ALP)活性的变化关系。结果表明,大鼠肾匀浆中 ALP活性明显低于对照组,尿 ALP活性则显著增加。ALP 活性降低的部位在肾近曲小管。体外实验未发现氯化汞对肾、尿ALP 具有直接抑制作用或激活作用。尿中ALP 活性的增高是汞引起的肾小管上皮细胞损伤所致。它可作为汞中毒肾损害的一个观察指标。By means of a subacute mercury poisoning renal damage model in rat,the changes of ALP activity in blood, kidney & urine were studied. The results showed that ALP activity in renal homogenate of mercury poisoning rats was significantly lower than that of the contral,& the ALP activity in urine of mercury group was significautly increased, Histochemical study revealed that the site of ALP activity decline is in renal proxtmal convoluted tubules ( PCT) . It was not fou nd that HgCI2 had direct: activation or inhibition on ALP in kidney & urine according to the results observed in vitro. Therefore it seems that increase of ALP activity in urine results from PCT damage by mercury & may be used as an indicator of mercury poisoning renal damage.

关 键 词：肾脏毒性 碱性磷酸酶 汞中毒 

分 类 号：R595.202[医药卫生—内科学]