甲醛和甲酸对人和动物细胞膜流动性的作用  

Effecta of formaldehyde and formic acid on erythrocyte membrane fluidity

作　　者：张瑞稳[1] 蒋学之[1] 潘小平[2] 

机构地区：[1]上海医科大学劳动卫生学教研室 [2]上海医科大学基础部化学教研室

出　　处：《卫生毒理学杂志》1989年第2期71-73,125,共4页Journal of Health Toxicology

摘　　要：在体外实验中,甲醛致兔红细胞膜流动性明显降低,最低作用浓度为0.05mM/L。甲酸亦有相似作用,最低作用浓度为0. 01mM/L,并存在一定的剂量-效应关系。体内给予甲醛3mg/kg即见红细胞膜流动性下降,与人红细胞体外实验结果一致。甲醛接触工人(空气浓度3mg/m^3)细胞膜流动性明显降低。Decreased erythrocyte membrane fluidity caused by formaldehyde and its metablite, formic acid was demonstrated in buman and in rabbits by in vino and in vitro bioassay. In vitro stud ies, decreased erythrocyte membrane fluidity was found in human and in rabbits with lowest effec tive dose of 0.05 m Mol/L of formaldehyde, or 0.01 m Mol/L of formic acid. The dose-effect relationship was also observed. In vivo studies, membrane fluidity was significantly decreased by venous injection of formaldehyde to rabbits at dose of 3 mg/kg. B.W. Membrans fluidity was significantly decreased in formaldehyde exposurers ( formaldehyde in air, 3 mg/m3 ) erythr ocytes. The results provided certain experimental evidence for undarstanding the mechanism of fo rmaldehyde effects on blood and cardiovascular system.

关 键 词：甲醛 甲酸 细胞膜 流动性 

分 类 号：R994.3[医药卫生—毒理学]