肉毒毒素结构及其重组疫苗的相关研究进展  

Development of the Structure and Recombinant Vaccines for Botulinum Neurotoxins

作　　者：杨秀清[1] 荫俊[1] 

机构地区：[1]军事医学科学院微生物流行病研究所,北京100071

出　　处：《生物技术通讯》2005年第2期183-185,共3页Letters in Biotechnology

摘　　要：肉毒毒素是肉毒梭状杆菌产生的外毒素,有7种血清型(A～G)。肉毒毒素属神经强毒,是目前已知的毒性最强的细菌蛋白质。作为重要的生物战剂之一,对肉毒毒素的研究已经相当深入,基本明确了各型肉毒毒素的基因序列、同源性和三维结构及毒素作用的本质和机理。随着国际恐怖活动的日益猖獗,针对肉毒毒素的检测和预防也备受关注,对其疫苗的探索已成为研究的焦点。本文扼要介绍了肉毒毒素的结构、作用机制及其疫苗的相关研究进展。Clostridium botulinum may produce any of seven known serotypes of neurotoxin(A～G), which are the most toxic bacterial proteins known. The gene and structures of different serotype of botulinum neurotoxins have been already known. Recently because of the terrior, the detection and prevention of botulinum neurotoxins have been important, especially the reaserch on vaccine are more significant. So the study on structures and vaccine of botulinum neurotoxins are discussed in this article.

关 键 词：肉毒毒素 结构 重组疫苗 肉毒梭状杆菌 外毒素 作用机制 

分 类 号：R996.1[医药卫生—毒理学] R392.1[医药卫生—药学]