超声微泡造影剂制备中乳化剂的选择  

Choice of emulsifier in the preparation of ultrasound contrast agent

作　　者：张雪娇[1] 程永清[1] 李丽君[2] 陈娜[1] 刘银凤[1] 

机构地区：[1]西北工业大学理学院应用化学系,陕西西安710072 [2]西安交通大学第二附属医院,陕西西安710003

出　　处：《中国医学影像技术》2005年第4期501-503,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金资助(30370579)。

摘　　要：采用乳液聚合法对微泡超声造影剂的制备进行研究,重点对反应中所必需的乳化剂进行选择,并在此基础上讨论了乳化剂的用量及配比等对实验结果的影响.由本方法所制得的微泡粒径以2～8 μm的居多,浓度在9.51×109 /ml左右,单体转化率达到71%,有利于更进一步的研究.The preparation of ultrasound contrast agent (UCA) by emulsion polymerization was studied. The study focus on the selection of the emulsifier which is necessary in the preparation. Then the effect of the emulsifier dose and ratio on the experimental results was studied. The microbubbles were prepared by this method had a diameter of 2 to 8 μm, concentration of 9.51×10 10 /ml,and the monomer conversion rate was up to 71%, worthy of much more research.

关 键 词：乳液聚合 乳化剂 单体转化率 超声造影剂 微泡 

分 类 号：R318.08[医药卫生—生物医学工程] R445.1[医药卫生—基础医学]