利用聚焦超声的声致发光技术检测不同组织的成像差异  

Detection of imaging difference in different tissues with sonoluminescence of focusing ultrasound

作　　者：丁春峰[1] 邢达[2] 郭洪[1] 

机构地区：[1]郑州大学河南省激光与光电信息技术重点实验室,河南郑州450052 [2]华南师范大学激光生命科学重点实验室,广东广州510631

出　　处：《中国医学影像技术》2005年第4期504-506,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金面上项目(60378043; 30470494);广东省自然科学基金项目 ( 015012; 04010394 );广东省科技计划项目(2004B10401011)。

摘　　要：目的　本文提出一种利用聚焦超声的声致发光,结合ICCD成像技术检测不同组织成像差异的方法。方法　实验样品为一块4 cm×4 cm×2 cm的猪的脂肪组织,中间埋入一块0.5 cm×0.5 cm×0.5 cm的血块,代表不同的组织层,利用聚焦超声对组织内的一层进行逐点扫描,然后对各点在超声作用下产生的发光强度进行二维图像重建,利用各点发光强度的差异得到组织样品的二维图像。结果　利用该方法能够清晰地得到脂肪组织中埋藏血块的二维分布,测量精度达到0.5 mm,测量深度达到1 cm。结论　该方法可望在乳腺癌等皮下肿瘤的早期诊断中得到应用。Objective To explore a new method for detecting the imaging difference in different tissue with focusing ultrasound combined with ICCD imaging technique. Methods The experimental sample was a 4 cm×4 cm×2 cm fat tissue of pig, in which a 0.5 cm×0.5 cm×0.5 cm gore was embedded. The lay in the tissues was scanned by focusing ultrasound, the sonoluminescence coming from the scan point with ICCD image system one by one were detected, and then the 2-D image of the scaned lay based on the different luminescence intensity of each scan point were rebuilt. Results The gore in the fat tissue could be detected distinctly with this method, the metrical precision was about 0.5 mm and the fathom was about 1 cm. Conclusion This method can be used in prophase diagnosis of tumor in under-skin tissue, especially in the diagnosis of galactophore tumor.

关 键 词：声致发光 ICCD成像系统 聚焦超声 

分 类 号：R445.1[医药卫生—影像医学与核医学] O426.3[医药卫生—诊断学]