氟伐他汀对心肌梗死大鼠左室重塑和功能的影响  

Effects of of fluvastatin on left ventricular remodeling and function after acute myocardial infarction in rats

作　　者：刘宇宏[1] 曾秋棠[1] 袁国会 陈斌[2] 

机构地区：[1]华中科技大学协和医院心内科华中科技大学同济医学院心血管病研究所,武汉430022 [2]华中科技大学同济医院超声影像科

出　　处：《临床心血管病杂志》2005年第4期233-236,共4页Journal of Clinical Cardiology

摘　　要：目的探讨羟甲基戊二酰辅酶A(HMGCoA)还原酶抑制剂氟伐他汀对急性心肌梗死(AMI)大鼠左室结构和功能的影响。方法雌性SD大鼠AMI后6h随机分为AMI组和氟伐他汀组;另设假手术组。三组大鼠直接灌胃给药或自来水8周后行高频多普勒超声、血流动力学、心脏重塑指标及左心室心肌α、β肌球蛋白重链(α、βMHC)mRNA表达的测定。结果与假手术组相比,AMI组左室舒张末期内径(LVEDD)、左室舒张末期容积(LVEDV)、E峰、E峰减速度、E/A、左室舒张末压(LVEDP)、左、右心室心肌肥厚指数、非梗死区胶原容积分数(CVF)和βMHCmRNA均明显增加(P<0.01),左室短轴缩短率(FS)、射血分数(EF)和αMHCmRNA显著降低(P<0.01)。与AMI组相比,氟伐他汀组的LVEDD、LVEDV、E峰、E峰减速度、E/A、LVEDP、左、右心室心肌肥厚指数、CVF和βMHCmRNA均显著降低或减少(P<0.01),FS、EF和αMHCmRNA显著升高(P<0.01)。结论氟伐他汀能抑制大鼠AMI后左室重塑,改善血流动力学异常和左室功能。Objective:To study the impact of fluvastatin on left ventricular remodeling (LVRM) and cardiac function after acute myocardial infarction (AMI) in rats.Method:Six hours after ligating left coronary artery, 42 surviving AMI female SD rats were randomly assigned to: AMI control (n=24) and ②fluvastatin(n=18). ③sham-operated group(n=10) are selected randomly as non-infarction control. After 8 weeks of therapy, cardiac function, hemodynamics, ventricular weight/body weight ratio, non-infarcted myocardial collagen volume fraction (CVF) and MHC mRNAs were investigated. Result:Compared with sham-operated group, left ventricular end-diastolic dimension(LVEDD), left ventricular end-diastolic volume (LVEDV), E-wave, E-wave deceleration, E-wave /A-wave velocity ratio, left ventricular end diastolic pressure(LVEDP), relative weight(LVRW), right ventricular relative weight(RVRW), CVF andβMHC mRNA were all significantly increased (all P<~0.01 ) in AMI group, while fractional shortening(FS), ejection fraction(EF) and αMHC mRNA were all significantly decreased (all P<~0.01 ). In comparison with AMI group, LVEDD, LVEDV, E-wave, E-wave deceleration, E/A, LVEDP, LVRW, RVRW, CVF and βMHC mRNA were all significantly decreased(all P<~0.01 ), while FS, EF,αMHC mRNA were all significantly increased(all P<~0.01 ) in fluvastatin group.Conclusion:Fluvastatin can prevent LVRM after AMI in rats, improve hemodynamics and LV function.

关 键 词：心肌梗死 氟伐他汀 心室重塑 左心室功能 

分 类 号：R542.2[医药卫生—心血管疾病]