Improvement of cardiac function after transplantation of autologous bone marrow mesenchymal stem cells in patients with acute myocardial infarction  

作　　者：陈绍良 方五旺 钱钧 叶飞 刘煜昊 单守杰 张俊杰 林松 廖联明 赵春华 

机构地区：[1]DepartmentofCardiology,NanjingFirstMunicipalHospital,NanjingMedicalUniversity,Nanjing210006,China [2]DepartmentofCardiology,MaanshanMunicipalPeople＇sHospital,Maanshan240058,China [3]TissueandEngineeringCentre,ChineseAcademyofMedicalSciences,Beijing100036,China

出　　处：《中国生物学文摘》2005年第3期92-97,共6页Chinese Biological Abstracts

摘　　要：Background The infarct size determines the long-term prognosis of patients with acute myocardial infarction (AMI). There is a growing interest in repairing scar area by transplanting bone marrow stem cells. However, effectiveness of intracoronary injection of bone marrow mesenchymal stem cells (BMSCs) in patients with AMI still remains unclear.Methods Sixty-nine patients with AMI ,after percutaneous coronary intervention (PCI) were randomly divided into intracoronary injection of BMSCs (n=34) and saline (control group, n=35) groups. Serial single positron emission computer tomography (SPECT) , cardiac echo and cardiac electromechanical mapping were done at the designed time intervals until six months after transplantation of BMSCs or injection of saline.Results The proportion with functional defect decreased significantly in the BMSCs patients after three months [(13±5)%] compared with that pre-transplantation [(32±11)%] and the control group [(28±10)%] at three month follow-up (P<0.05, respectively) . Wall movement velocity over the infracted region increased significantly in the BMSCs group [(4.2±2.5)cm/s vs (2.2±1.3)cm/s, P<0.05], but not in the control group [(2.2±1.5)cm/s vs (2.7±1.7)cm/s, P>0.05]. Left ventricular ejection fraction (LVEF) three months after transplantation in BMSCs group increased significantly compared with that pre-implantation and with that of the control group at three months post'injection [(67±11)% vs (49±9)% and (53±8)%, P<0.05 respectively]. SPECT scan results showed that perfusion defect was improved significantly in BMSCs group at three-month follow-up compared with that in the control group [(134±66)cm^2 vs (185±87)cm^2, P<0.01]. At the same time, left ventricular end-diastolic volume [(136±31)ml vs (162±27)ml, P<0.05] and end-systolic volume [(63±20)ml vs (88±19)ml, P<0.05] decreased synchronously. The ratio of end-systolic pressure to end-systolic volume [Psyst/ESV, (2.84±1.30)mmHg/ml vs (1.72±1.23)mmHg/ml, P<0.05] increased significantly. Cardiac electromechn

关 键 词：急性心肌梗死 骨髓间叶干细胞 细胞移植 强心剂 自体移植 

分 类 号：R542.22[医药卫生—心血管疾病] R457.7[医药卫生—内科学]