红景天对心脏血液动力学及心肌收缩力的影响(英文)  

Effect of rhodiola sacra SH Fu on heart hemodynamics and myocardial contractility

作　　者：莫书荣[1] 鲁波[1] 连芳[1] 

机构地区：[1]广西医科大学生理学教研室,广西壮族自治区南宁市530021

出　　处：《中国临床康复》2005年第11期204-206,共3页Chinese Journal of Clinical Rehabilitation

基　　金：广西科学基金资助项目(桂科自0229036)~~

摘　　要：背景:红景天具有抗衰老、抗疲劳、提高人体免疫力的作用,并可缓解心绞痛。目的:研究红景天对心脏的血液动力学及心肌收缩力的影响,并探讨其机制。设计:以实验动物为研究对象的观察对比研究。单位:一所医科大学的生理学教研室。材料:实验于2001-01/2001-04在广西医科大学生理学教研室心血管研究实验室进行。新西兰大白兔30只,雌雄不限,体质量1.9～2.3kg,随机分为2组,对照组(生理盐水4mL/kg)和红景天(诺迪康)组(0.5g/4mL·kg),每组15只。普通野生青蛙100只,体质量-1120～160g,随机分为4组,即生理盐水对照组、诺迪康小剂量组(血药浓度209mg/L)、诺迪康中剂量组血药浓度418mg/L)和诺迪康大剂(量组(血药浓度627mg/L),每组25只。方法:运用ms2000多媒体生物信号分析系统,经Straub法制备离体蛙心灌流标本并检测心脏活动,利用血液动力学方法检测大白兔的心室活动等相关指标。主要观察指标:两组家兔心脏血液动力学变化的比较,不同剂量诺迪康对离体蛙心工作影响的比较。结果:各诺迪康组的心肌收缩力比对照组的明显增强(F=8.939,P<0.01),209,418,627mg/L诺迪康组的心肌收缩力呈现递增趋势,分别增强52.3%,70.1%,86.4%,但各实验组间未达显著差异(P>0.05);各组之间的蛙心心率也无显著性差异(P>0.05)。大白兔血液动力学?BACKGROUND:Rhodiola rosea L acts on anti aging,anti fatigue and improving immunity in human body and improves angina pectoris.OBJECTIVE:To study the effect of rhodiola root on heart hemodynamics and myocardial contractility and probe into its mechanism.DESIGN:Observational and controlled based on the experimental animals.SETTING:Department of physiology in a medical university.MATERIALS:The experiment was performed in Laboratory of Cardiac Vessels of Department of Physiology of Guangxi Medical University from January to April 2001.Thirty New Zealand white rabbits of either sex,weighted varied from 1.9 to 2.3 kg,were randomized into two groups,named as the control(physiological saline 4 mL/kg) and rhodiola sacra SH Fu(nuodikang) group(0.5 g/4 mL· kg- 1),15 rabbits in each group.A hundred common wild frogs were employed, weighted varied from 120 to 160 g,randomized into 4 groups,named as the control group of physiological saline,nuodikang of small dosage group(blood concentration 209 mg/L),nuodikang of moderate dosage group(blood concentration 418 mg/L) and nuodikang of large dosage group(blood concentration 627 mg/L),25 frogs in each group.METHODS:ms2000 multiple medium biological signal analysis system was applied,by Straub method,frog heart perfusion specimen in vitro was prepared and the cardiac activity was assayed.The relevant indexes of ventricle activity in rabbits were determined with hemodynamics.MAIN OUTCOME MEASURES:Comparison of hemodynamics changes in rabbits of two groups and the comparison of effects of nuodikang at various dosages on frog heart work in vitro.RESULTS:Myocardial contractility in every nuodikang group was strengthened remarkably compared with the control(F=8.939,P< 0.01),the myocardial contractility in nuodikang groups at the dosages of 209 mg/L,418 mg/L and 627 mg/L was in the tendency of increasing,strengthened by 52.3% ,70.1% and 86.4% respectively.But the significant difference was not apparent in the comparison among experimental groups(P >0.05).The significant difference

关 键 词：红景天 血液动力学 心肌收缩 

分 类 号：R542.2[医药卫生—心血管疾病]