消旋聚乳酸输尿管支架管体外降解:时间及结构变化  

In vitro degradation of poly-DL-lactic acid ureteral stent: biodegradation time and structure

作　　者：王炜[1] 刘钰[2] 徐缓[3] 姜勇[3] 杨宇如[4] 李虹[4] 

机构地区：[1]东莞市人民医院泌尿外科,广东省东莞市523018 [2]中国科学院成都有机化学研究所,四川省成都市610041 [3]四川大学华西医院病理科,四川省成都市610041 [4]四川大学华西医院泌尿外科,四川省成都市610041

出　　处：《中国临床康复》2005年第14期36-37,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:观察以单分子乳酸为原料合成的消旋聚乳酸输尿管支架管的体外降解变化,是否符合人体输尿管损伤修复时管架体内存留4～6周后降解的时间要求。方法:实验于2002-02/12在中国科学院成都有机化学研究所和四川大学华西医院完成。以单分子乳酸在180℃、压力为0.67kPa的环境中以三氧化二锑为催化剂合成消旋丙交酯,再将消旋丙交酯及引发剂经开环聚合途径合成消旋聚乳酸并制成输尿管支架管,将支架管置于磷酸盐缓冲液中观察其大体形态变化,在电镜下观察支架管材料结构的降解变化。观察材料降解后产物的特征。结果:①消旋聚乳酸支架管降解前分子量为68900。支架管外径约3.0～4.0mm,内径2.0～3.0mm。②支架管在降解过程中,逐渐变为空泡状结构,6周时柔韧性逐渐降低、脆性逐渐增加,至8周时支架管形态消失,逐步降解为细小的团状物。③在电镜下,支架管表面的孔隙逐渐增多增大,支架管材料不断被浸析、降解。结论:消旋聚乳酸可降解输尿管支架管,降解时间及其产物符合输尿管组织修复的需要,可能是较为理想的输尿管支架管组织修复的高分子材料之一。AIM:To synthesize poly DL lactic acid(PDLLA) ureteral stent with mono lacti c acid and observe the degradation changes of the stent in vitro to judge whethe r the PDLLA ureteral stent can remain in vivo for 4 to 6 weeks after degradation ,accordant with the time for the repair of human ureteral injury. METHODS:The experiment was conducted in Chengdu Institute of Organic Chemistry affiliated to Chinese Academy of Sciences and Huaxi Hospital of Sichuan Univers ity from February to December 2002.Mono lactic acid was synthesized into racemi c lactide using Sb2O3 as the catalyzer at 180 ℃under 0.67 kPa,and then the lact ide plus primosome was synthesized into PDLLA ureteral stents by ring opening po lymerization.The stents were immersed in phosphate buffer solution to observe th eir gross change,and the structural degradation was checked under electron micro scope.The characteristics of products after degradation of the stents were also observed. RESULTS:①The molecular mass of PDLLA stents was 68 900.The outer and inner di ameter was 3.0 to 4.0 mm and 2.0 to 3.0 mm respectively.②The stents became bubb le like in appearance,and got to be more fragile and less flexible during degra dation.The original form of stents disappeared completely till the eighth week,a nd then they were degraded into fine mass like products.③Along with the degrad ation,the micro pores in the stents increased in number and diameter,and the st ents were gradually immersed and degraded obeserved under electron microscope. CONCLUSION:PDLLA can degrade ureteral stents,and the degradation time and prod ucts are suitable for the repair of ureteral injury,so PDLLA might be one of the ideal high polymer materials for degradable ureteral stents.

关 键 词：乳酸盐类 生物降解 输尿管 支架 

分 类 号：R289[医药卫生—方剂学]