四氯化碳大鼠灌胃慢性中毒的肝脏病理组织学变化  

The Pathohistological Change for the Liver of Carbon Tetrochloride Chronic Poisoning by Mouth in Rat

作　　者：郭海恩[1] 关迺源 马凤[1] 徐坤[1] 李学明[1] 

机构地区：[1]中国预防医学科学院环境卫生与卫生工程研究所

出　　处：《卫生研究》1989年第6期13-16,共4页Journal of Hygiene Research

摘　　要：本文介绍了四氯化碳慢性中毒实验所致的肝脏病理组织学的变化。经光镜和电镜观察的结果表明,0.2mg/kg可致大鼠肝细胞出现脂肪变性、点状坏死,肝细胞内胶原纤维蓄积和细胞间质纤维组织增生。0.02mg/kg为最大无作用剂量。This article presents the pathohistological change for the liver of car- bon tetrochloride chronic poisoning. By light and electron microscopic studies, the result shows that 0.2 mg/kg can cause the fatty degeneration and the necrosis of the liver cells, the accumulation of collagenous fiber in the liver cells and the hyperplasia of the interstitial fiber. 0.02 mg/kg is the maximal no-effect level.

关 键 词：四氯化碳中毒 胶原纤维 肝脏病理 

分 类 号：R595.102[医药卫生—内科学]