激光诱导荧光光谱区分正常和斑块动脉及对其生物学机制的研究  

Differentiation of Normal Aorta and Atherosclerotic Plaques by Laser Induced Fluorescence and Its Biochemical Basis

作　　者：施波[1] 郑道声[1] 张世华[1] 包世宏[1] 盖保康[1] 夏罗林 陈扬骎[2] 程关锠 

机构地区：[1]上海第二医科大学附属仁济医院心脏内科 [2]上海市激光技术研究所

出　　处：《中国激光医学杂志》1994年第4期210-214,共5页Chinese Journal of Laser Medicine & Surgery

摘　　要：采用３３７ｎｍＮ２激光诱导动脉荧光，以荧光光谱区分粥样硬化斑块和正常动脉壁的阳性率８４％，阴性率１００％，正确率８９．５％。弹性蛋白和胶原蛋白是动脉的主要荧光物质。弹性蛋白是构成正常动脉荧光光谱的主要成分。胶原蛋白增生导致粥样硬化斑块的荧光光谱异于正常动脉。钙和胆固醇也可能影响粥样硬化斑块的荧光光谱。Laser induced fluorescence (LIF) using nitrogen laser at the wavelength of 337nm is exploited for discriminating normal and atherosclerotic aorta in vitro The normal aorta and the atherosclerotic plaques can be distinguished by the classification score with a positive rate of 84%, a negtive rate of 100% and an accuracy of 89 5% Elastin and collagen are the major substences producing fluorescence in normal or atherosclerotic aortic walls Elastin is the main fluorophore in normal aortic wall, while collagen proliferation causes the LIF of plaques to differ from that of normal intima The presence of calcified mass and cholesterol may also affect the LIF of atherosclerotic plaques

关 键 词：激光诊断 荧光光谱 动脉粥样硬化 病理学 

分 类 号：R543.504[医药卫生—心血管疾病] R541.404[医药卫生—内科学]