卡拉胶寡糖对放射损伤的防护作用  

Radioprotective effect of carrageenan-derived oligosaccharides on mice with radiation injury

作　　者：李翊[1] 王海青[1] 

机构地区：[1]解放军第四○一医院放射科,青岛266071

出　　处：《中华放射医学与防护杂志》2005年第2期116-117,共2页Chinese Journal of Radiological Medicine and Protection

基　　金：山东省攻关计划基金资助项目(031070120)

摘　　要：目的探讨卡拉胶寡糖对受60GyX射线照射小鼠的辐射防护作用。方法采用6MVX直线加速器一次全身照射BALBc小鼠,3个卡拉胶寡糖组照射前连续14d和照射后继续给药7d。观察小鼠30d存活率、外周血白细胞总数、胸腺指数和脾脏指数、脾脏NK细胞活性和腹腔巨噬细胞吞噬功能。结果卡拉胶寡糖组小鼠30d存活率比照射对照组提高75%～90%;而且卡拉胶寡糖能加速小鼠外周血白细胞的恢复,明显提高胸腺指数和脾脏指数,激活脾脏NK细胞的杀伤活性,增强巨噬细胞吞噬功能。结论卡拉胶寡糖对受照射小鼠有明显的辐射防护作用。Objective To study the radioprotection effect of the carrageenan-derived oligosaccharides on irradiated mice. Methods The carrageenan-derived oligosaccharides were applied to BALB/c mice daily for successive 14 days before whole-body irradiation with 6.0 Gy X-rays and for 7 days after the irradiation.The 30-day survival rate,counts of peripheral white blood cells,thymus and spleen index,cytostatic activity of NK,and peritoneal macrophage phagocytosis were studied. Results The 30-day survival rate elevated from 75% in the control group to 90% in the oligosaccharides-treated group.The carrageenan-derived oligosaccharides significantly promoted recovery of peripheral white blood cells,markedly increased thymus and spleen index,NK cytostatic activity and peritoneal macrophage phagocytosis. Conclusion The carrageenan-derived oligosaccharides has marked radioprotective effect on irradiated mice.;

关 键 词：卡拉胶 寡糖 放射损伤 巨噬细胞吞噬功能 BALB/c小鼠 辐射防护作用 NK细胞活性 外周血白细胞 照射小鼠 脾脏指数 胸腺指数 直线加速器 白细胞总数 全身照射 杀伤活性 X射线 6MV 存活率 对照组 

分 类 号：R818[医药卫生—放射医学]