蒿甲醚治疗实验大鼠肺孢子虫肺炎的初步观察  

AN EXPERIMENTAL TRIAL OF ARTEMETHER IN TREATMENT OF PNEUMOCYSTIS CARINII PNEUMONIA IN THE IMMUNO SUPPRESSED RAT MODEL

作　　者：陈雅棠[1] 马良[1] 梅芹[1] 

机构地区：[1]重庆医科大学传染病寄生虫病研究所

出　　处：《中国寄生虫病防治杂志》1994年第4期278-281,共4页Chinese Journal of Parasitic Disease Control

摘　　要：用皮下连续注射醋酸可的松６周建立大鼠肺孢子虫肺炎动物模型，并用国产蒿甲醚进行实验治疗。经蒿甲醚１００ｍｇ／ｋｇ·次，每日１次连续５ｄ，大腿肌肉注射后，治疗组大鼠肺印片中卡氏肺孢子虫包囊均数较未治疗对照组有所减少，而与戊烷脒治疗组相近，提示蒿甲醚可能是一种有前途的抗卡氏肺孢子虫新药。An immunosuppressed rat model was established by injection subcuteneously with cortisone acetate twice a week,a development of Pneumocystis carinii pneumonia was found at the end of 6th week in all rats. These rats were injected intramuscularly with artemether of 100mg/kg once a day for 5 days. All rats were necropsied at the end of 8th week.The lung im-pression smears were stained with Gomori’s methenamine silver. Pneumocystis carinii cysts were counted under microscopy( 1 600 ×),and the average and standard deviations(SD)were calculat-ed.Statistical analysis was taken by“t”test. All slides were randomized and then examined by two researchers using a blinded protocal. The preliminary results reported herein showed that the av-erage number of cysts in the groups E and F which were treated with artemether were 2.01 and 6.60/field(1600×)respectively,and were lower than that of the non─treated control groups,similar to the average number of group G treated with pentamidine. This result suggests that artemether may be a potential anti─Pneumocystis carinii drug.

关 键 词：蒿甲醚 卡氏肺孢子虫 动物模型 肺炎 

分 类 号：R978.61[医药卫生—药品]