苯芴醇与青蒿琥酯伍用治疗抗药性恶性疟疗效观察  

EFFICACY OF BENFLUMETOLUM/ARTESUNATE AGAINST THE DRUG-RESISTANT FALCIPARUM MALARIA

作　　者：车立刚[1] 张有林[1] 李兴亮[1] 杨亚明[1] 李春富[1] 刘慧[1] 

机构地区：[1]云南省疟疾防治研究所

出　　处：《中国寄生虫病防治杂志》1994年第4期259-261,共3页Chinese Journal of Parasitic Disease Control

基　　金：WHO/WORLDBANK/TDR资助

摘　　要：苯芴醇１６００ｍｇ与青蒿琥酯４００ｍｇ３ｄ分服治疗抗药性恶性疟５６例，退热时间３３．３±１４．５ｈ，原虫无性体转阴时间３４．１±９．７ｈ，２８ｄ根治率１００％，无明显不良反应，对配子体形成和原虫孢子增殖有一定抑制效果，疗程和剂量均低于单方组，疗效也较单方组为优，是治疗抗药性恶性疟的适宜方案。Fifty-six patients suffering from drug-resistant falciparum malaria were treat-ed with 1600 mg benflumetolum and 400 mg artesunate for 3 days. As a result, fever subsidencetime was 33.3、14.5h,asexual parasite clearance time 43.1、9.7 h and radical cure rate was100%during a 28-day-follow-up.No side effect was observed. This treatment can inhabitgametocytogenesis and sporogony to some extent.The course of this treatment was shorter thanthat of single benflumetolam.Its dosage was less than that of the latter one and its efficacy wasmuch higher.It is a suitable method for treating the drug resistant falciparum malaria.

关 键 词：抗药性 恶性疟 苯芴醇 青蒿琥酯 疟疾 

分 类 号：R978.61[医药卫生—药品] R531.305[医药卫生—药学]