云南南部恶性疟原虫对甲氟喹、奎宁、氨酚喹、氯喹、磺胺多辛／乙胺嘧啶及咯萘啶敏感性的体外测定  

IN VITRO SENSITIVITY OF PLASMODIUM FALCIPARUM TO MEFLOQUINE, QUININE,AMODIAQUINE,CHLOROQUINE,PYRONARIDINE AND SULFADOXINE/PYRIMETHAMINE IN SOUTH YUNNAN 

作　　者：杨恒林[1] 杨品芳[1] 杨亚明[1] 

机构地区：[1]云南省疟疾防治研究所

出　　处：《中国寄生虫学与寄生虫病杂志》1994年第2期140-142,共3页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：卫生部青年科学基金

摘　　要：１９９２年１０－１２月在云南南部应用体外微量法测得甲氟喹、奎宁、氨酚喹、氯喹、磺胺多辛／乙胺嘧啶（磺／乙）及咯萘啶对恶性疟原虫的ＩＤ５０依次为４６、４８０、５２、１５０、２×１０４／２５×１０２及１５ｎｍｏｌ／Ｌ；ＩＤ９５分别为１６０、１５３６、２９２、６８０、２４×１０５／３×１０５及６０ｎｍｏｌ／Ｌ。恶性疟原虫对甲氟喹，奎宁均敏感；对氨酚喹及氯喹的抗性率分别为１００％（３０／３０）及９６．７％（２９／３０）；咯萘啶测定５例，其中１例显示有抗性。２０例中有１３例的恶性疟原虫可在最高药量磺／乙井中发育至裂殖体。提示当地恶性疟原虫对氯喹与氨酚喹有明显交叉抗性，对奎宁与甲氟喹可能有交叉抗性。The sensitivity of P.falciparum to mefloquine,quinine,amodiaquine,chloroquine,pyronaridine,and sulfadoxine/pyrimethamine(MEF,QNN,AMO,CHL,PYR,S/P)was tested using in vitro microtest in south Yunnan Province in 1992.The ID 50 were 46,480,52,150,15 and 2×10 4/25×10 2 nmol/L,respectively;ID 95 were 160,1 536,292,680,60 and 24×10 5/ 3× 10 5 nmol/L,respectively.All the isolates(30) were sensitive to MEF and QNN;100%(30/30)and 96.7%(29/30) isolates were found to be resistant to AMO and CHL,the cross resistance rate was 100% to the two drugs.One of 5 isolates exhibited resistance to PYR.The results suggest that the P.falciparum was susceptible to MEF and QNN,but was resistant to AMO,CHL and S/P. CHL resistant P.falciparum showed a marked cross resistance to AMO,but not to MEF,QNN,and S/P;AMO resistant P.falciparum exhibited cross resistance to CHL,but not to MEF,QNN,and S/P.

关 键 词：疟原虫 体外微量法 甲氟喹 氟酚喹 

分 类 号：R382.31[医药卫生—医学寄生虫学]