阿托伐他汀及血管紧张素Ⅱ对人体脂肪组织白细胞介素6及Ⅰ型纤溶酶原激活剂抑制物分泌的影响  

The Effect of Atorvastatin and AngiotensinⅡ on the Release of Interleukin-6 and Type-Ⅰ-Plasminogen-Activator-Inhibitor from Human Adipose Tissue

作　　者：赵水平[1] 王小清[2] 李全忠[1] 唐汉权[2] 

机构地区：[1]中南大学湘雅二医院心内科,湖南省长沙市410011 [2]中南大学湘雅二医院老年病科,湖南省长沙市410011

出　　处：《中国动脉硬化杂志》2005年第1期73-75,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的　观察不同部位脂肪组织的分泌功能 ,以及血管紧张素Ⅱ和他汀类药物对脂肪组织分泌白细胞介素 6和Ⅰ型纤溶酶原激活剂抑制物的影响。方法　检测体外培养的人内脏及腹部皮下脂肪组织在加用阿托伐他汀及血管紧张素Ⅱ作用前后白细胞介素 6和Ⅰ型纤溶酶原激活剂抑制物的分泌水平。结果　内脏脂肪组织分泌白细胞介素 6 (16 5 3± 339pg/ g组织 )高于皮下脂肪组织 (116 3± 733pg/ g组织 ,P <0 .0 1) ,内脏脂肪组织分泌Ⅰ型纤溶酶原激活剂抑制物 (10 0± 30ng/ g组织 )也高于皮下脂肪组织 (6 8± 14ng/ g组织 ,P <0 .0 1)。内脏及皮下脂肪组织分泌的白细胞介素 6与体质指数呈正相关 (r分别为 0 .85和 0 .6 9,P <0 .0 1)。内脏及皮下脂肪组织分泌的Ⅰ型纤溶酶原激活剂抑制物与体质指数呈正相关 (r分别为 0 .6 3和 0 .71,P <0 .0 1)。血管紧张素Ⅱ使内脏及皮下脂肪分泌白细胞介素 6分别增加 19%和 18% ,使内脏及皮下脂肪分泌Ⅰ型纤溶酶原激活剂抑制物分别增加 15 %和 14 % ;阿托伐他汀使内脏及皮下脂肪分泌白细胞介素 6分别减少 2 5 %和 2 1% ,使内脏及皮下脂肪分泌Ⅰ型纤溶酶原激活剂抑制物分别减少 17%和 16 %。结论　人体不同部位的脂肪组织分泌炎性细胞因子和纤溶物质存在差异 ,且与肥胖有关。血管紧张?Aim To detect the secretion of different adipose tissue and observe the effect of angiotensin Ⅱ and statin on release of interleukin-6(IL-6) and type-Ⅰ-plasminogen-activator-inhibitor(PAI-1) from human adipose tissue. Methods The human omental and subcutanoems adipose tissues were cultured. The concentration of IL-6 and PAI-1 in media were measured by enzyme-linked immunosorbent assay(ELISA). Results IL-6 released from omental adipose tissue (1 653±339 pg/g tissue) was higher than that from subcutaneous adipose tissue (1 163±733 pg/g tissue, P<0.01), PAI-1 released from omental adipose tissue (100±30 ng/g tissue) is higher than that from subcutaneous adipose tissue (68±14 ng/g tissue, P<0.01) too. IL-6 released from omental and subcutaneous adipose tissue was postively associated with BMI. (r=0.85, 0.69, respectively, both P<0.01). PAI-1 released from omental and subcutaneous adipose tissue is postively associated with BMI (r=0.63, 0.67 respectively, both P<0.01). Angiotensin increased the release of IL-6 from omental and subcutaneous tissue by 19% and 18%, and that of PAI-1 by 15% and 14%, respectively. Atorvastatin suppressed IL-6 release from omental and subtaneouse adipose tissue by 25% and 21%, and suppressed PAI-1 release from omental and subcutaneous adipose tissue by 17% and 16% respectively. Conclusions Adipose tissue can secrete some kinds of cytokine and substances which are associated with obesity. The effect can be stimulated by angiotension and suppressed by atorvastatin.

关 键 词：内科学 阿托伐他汀 脂肪组织培养 白细胞介素6 Ⅰ型纤溶酶原激活剂抑制物 血管紧张素Ⅱ 酶联免疫吸附测定法 

分 类 号：R5[医药卫生—内科学]