盐酸西布曲明对单纯性肥胖大鼠血脂和心功能改变的影响  

REGULATION OF SERUM LIPIDS AND CARDIAC FUNCTION BY SIBUTRAMINE HYDROCHLORIDE IN SIMPLE OBESITY RATS MODEL

作　　者：陈奇[1] 嘉红云[2] 龙玲玲[2] 

机构地区：[1]广东省人民医院药学部,广州510080 [2]广东药学院临床医学系儿科学教研室,广州510224

出　　处：《海南医学院学报》2005年第2期98-101,共4页Journal of Hainan Medical University

摘　　要：目的:研究盐酸西布曲明对单纯性肥胖大鼠减肥作用及心功能改变的影响。方法:给刚断奶的雄性W ister大鼠饲喂营养性饲料8周后,养成营养性肥胖模型,分组给药,连续6周。结果:盐酸西布曲明每日10m g/kg,灌胃给药,能明显降低单纯性肥胖大鼠的体重、Lee's指数及血清甘油三酯水平。降低肥胖大鼠左心室收缩压、明显降低左心室舒张末压、增加左心室最大收缩速率及增加左心室最大舒张速率。结论:盐酸西布曲明灌胃给药对单纯性肥胖大鼠有明显的减肥降脂作用及改善心功能作用。Objective: To study the effects of sibutramine hydrochloride on obesity and cardiac function in alimentary obesity rats. Methods: Male wister rats were made to be the alimentary obesity model from a hyper-alimentary diet from weaning until 21 days of age for 8 weeks. Then, the rats were divided into two groups: the treatment group with sibutramine (10 mg/kg, orally) plus normal diet and control group with placebo plus normal diet for 6 weeks. Results: Sibutramine could not only markedly decreased the obesity rats weight and Lee's index and level of triglycericle in serum of the rats, but also decreased left ventricular systolic pressure (LVSP) , and left ventricular end-diastolic pressure (LVEDP). The added maximum rates of systole and diastole pressure (dp/dtmax) were also detected in sibutramine group. Conclusion: Sibutramine hydrochloride has an anti-body obesity effect and improves cardiac function for the alimentary obesity rats.

关 键 词：盐酸西布曲明 心功能改变 单纯性肥胖 大鼠血脂 WISTER大鼠 营养性肥胖模型 左心室舒张末压 肥胖大鼠 左心室收缩压 甘油三酯水平 减肥作用 灌胃给药 功能作用 降脂作用 Lee 速率 

分 类 号：R589.2[医药卫生—内分泌] R595.502[医药卫生—内科学]