联合脏器移植的临床疗效观察  

A clinical study on simultaneous multiorgan transplantation

作　　者：王共先[1] 刘通[1] 邓顺中[1] 胡红林[1] 秦克旺[1] 彭贵祖[1] 揭志刚[1] 曹润福[1] 谢平[1] 王道仁[1] 

机构地区：[1]江西医学院一附院泌尿外科,江西医学院泌尿外科研究所,南昌330006

出　　处：《江西医药》2005年第4期188-190,共3页Jiangxi Medical Journal

基　　金：赣沪科技合作项目

摘　　要：目的总结胰-肾和肝-肾联合移植术的临床经验。方法1例糖尿病合并尿毒症的患者行经门静脉-小肠引流的胰-肾联合移植术;1例肝炎后肝硬化合并尿毒症的病人施行肝-肾联合移植术。术后均采用普乐可复、霉酚酸酯和激素的三联免疫抑制剂治疗,观察其临床疗效。结果2例患者术后转氨酶、尿素氮和肌酐恢复正常。胰-肾联合移植患者术后停用外源性胰岛素,血糖、C肽恢复正常。随访12～18个月移植物功能良好。结论联合脏器移植是治疗多器官功能衰竭的有效手段,能提高患者的生活质量,恢复正常的生活和工作。Objective To conclude the clinical efficiency of simultaneous pancreas-kidney transplantation and liver-kidney transplantation. Methods A case of type 2 diabetes with end-stage renal disease was treated with simultaneous pancreas-kidney transplantation with enteric drainage.A case of viral hepatitis with renal failure was performed with simultaneous liver-kidney transplantation.The patients were received three drugs(tacrolimus,mycophenolate mofetil,prednisone)based immunosuppressive therapy postoperation. Results Liver and kidney function of the two patients were normal within 7 days.Exogeneous insulin was withdrawn from the patient of pancreas-kidney transplantation .The blood glucose and C-Peptide were normal.The grafts function was normal within 12～18 months following up. Conclusion Simultaneous multiorgan transplantation is an effective therapy to patients with multiple organ failure.It can improve the living quality of patients.

关 键 词：脏器移植 临床疗效观察 肝-肾联合移植术 三联免疫抑制剂 胰-肾联合移植 多器官功能衰竭 外源性胰岛素 肝硬化合并 临床经验 经门静脉 普乐可复 霉酚酸酯 生活质量 尿毒症 患者 肝炎后 糖尿病 术后 转氨酶 恢复 尿素氮 

分 类 号：R617[医药卫生—外科学] R743.33[医药卫生—临床医学]