虎参痛风胶囊对大鼠足肿的抗炎作用  

Exprimental research of anti-inflammation effect of Hushentongfeng capsules in the swelling paw in rat

作　　者：王燕燕[1] 陈超[2] 杨洪发[1] 

机构地区：[1]三峡大学第一临床医学院,湖北宜昌443003 [2]三峡大学医学院药理学教研室,湖北宜昌443002

出　　处：《中国医院药学杂志》2005年第3期206-208,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:研究虎参痛风胶囊的抗炎效果及对足肿胀组织前列腺素E2 (PGE2 )含量的影响。方法:分别观察虎参痛风胶囊500,250,125 mg·kg-13个剂量组对蛋清所致的大鼠足肿胀的影响。同时测定肿胀的足组织中PGE2 的含量。结果:虎参痛风胶囊能显著抑制蛋清所致的大鼠足肿胀程度,减少肿胀的足组织中PGE2 的含量。结论:虎参痛风胶囊有明显的抗炎作用。其抗痛风的机制部分是通过减少PGE2 的产生和聚集来实现的。OBJECTIVE To observe the anti-inflammation effect of Hushentongfeng capsules(Hus)and the influence on the level of prostaglandin E_2 (PGE_2) in the swelling paw of rat.METHODS To observe the influence of Hus at low, medial, high concentrations ig in rat on egg-white-induced paw swelling and to detect the level of PGE_2 in the swelling paw.RESULTS The tests indicated Hus could relieve swelling reaction caused by egg-white, and reduce the level of PGE_2 in swelling paw in rat.CONCLUSION Hus has significant anti-inflammation action, and has therapeutic effect on gout partly by prohibiting the generation and reducing the level of PGE_2 in focal lesions of acute gouty arthritis.

关 键 词：虎参痛风胶囊 抗炎 前列腺素E2 

分 类 号：R971.1[医药卫生—药品] R285.5[医药卫生—药学]