高效液相色谱法测定胃痛七味散胶囊中桂皮醛的含量  

Determination of cinnamaldehyde in Weitong Qiweisan capsules by HPLC

作　　者：李生有[1] 

机构地区：[1]青海省人民医院,青海西宁810007

出　　处：《中国医院药学杂志》2005年第3期248-249,共2页Chinese Journal of Hospital Pharmacy

摘　　要：目的：建立胃痛七味散胶囊中桂皮醛的高效液相色谱测定方法。方法：采用HYPERSILBDS C18 10μm相色谱柱(4．6mm×150mm，5μm)；流动相为甲醇-水-醋酸(45：55：0．2)。流速为1．0mL·min^-1；检测波长为280nm。结果：平均回收率为98．73％。RSD为0．49％。方法重现性的RSD为1．53％(n=5)。桂皮醛线性范围为0．2941．472μg(r=0．9995)。结论：本法操作简便。结果准确，可用于胃痛七味散胶囊的质量控制。OBJECTIVE To establish an HPLC method for determination of cinnamaldehyde in Weitong Qiweisan capsules. METHODS Using METHODS C_ 18 10μm column( 4.6 mm× 150 mm),the mobile phase was methanol-water-acetic acid(45∶55∶ 0.2), at flow rate of 1.0 mL·min -1 the UV detection wavelength was 280 nm.RESULTS The average recovery was 98.73% RSD was 0.49%. The RSD of the repeatability test was 1.53%(n=5).CONCLUSION The method is simple and accurate and can be used for the quality control of Weitong Qiweisan capsules.

关 键 词：高效液相色谱法 胃痛七味散胶囊 桂皮醛 

分 类 号：R927.2[医药卫生—药学]