头孢吡肟对儿科常见G-杆菌体外抗菌活性的研究  

In vitro antibacterial activity of cefepime against isolates of gram negative bacilli strains in children

作　　者：柳锡永[1] 陈淑君[1] 

机构地区：[1]浙江省义乌市中心医院,浙江义乌322000

出　　处：《儿科药学杂志》2005年第2期16-17,共2页Journal of Pediatric Pharmacy

摘　　要：目的:评价头孢吡肟对儿科常见革兰阴性杆菌的体外抗菌活性。方法:采用ATBG鄄5药敏分析仪测定头孢吡肟对革兰阴性杆菌的敏感性,并与头孢他啶、头孢噻肟、阿莫西林+克拉维酸、哌拉西林+他唑巴坦作对比研究。结果:总敏感率依次为哌拉西林+他唑巴坦73.3%、阿莫西林+克拉维酸62.6%、头孢吡肟61.8%、头孢他啶58.8%、头孢噻肟51.3%。头孢吡肟对鲍曼不动杆菌、大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌的敏感率分别为82.4%、70.3%、65.6%、27.3%,与头孢他啶、头孢噻肟、阿莫西林+克拉维酸、哌拉西林+他唑巴坦比较,无显著差异(P>0.05);对铜绿假单胞菌敏感率31.3%,明显低于头孢他啶、哌拉西林+他唑巴坦(χ2=4.50,P<0.05)。结论:头孢吡肟对鲍曼不动杆菌、大肠埃希菌、肺炎克雷伯菌均有强大的体外抗菌活性,对铜绿假单胞菌的体外抗菌活性不如头孢他啶、哌拉西林+他唑巴坦。Objective: To evaluate the in vitro antibacterial activity of cefepime against clinical isolates of gram negative bacilli strains in children. Methods: The susceptibility of cefepime against gram negative bacilli strains were determined by ATB G-5 drug sensitivity analyzer of French Bio-Merieux Company and compared with those of ceftazidime, cefotaxime, amoxicillin+potassium and piperacillin+tazobactam. Results: The rank order of susceptibility rate of the five agents was piperacillin+tazobactam 73.3%, amoxicillin+potassium 62.6%, cefepime 61.8%, ceftazidime 58.8% and cefotaxime 51.3%?The susceptibility rates of cefepime against acinetobacter baumannii, escherichia coli, klebsiella pneumoniae and enterobacter cloacae were 82.4%, 70.3%, 65.6% and 27.3% respectively. There was no significant difference between ceftazidime, cefotaxime, amoxicillin+potassium and piperacillin+tazobactam (P>0.05). Against pseudomonas aeruginosa, the susceptibility rate of cefepime (31.3%) was lower than that ceftazidime and piperacillin+tazobactam ( χ2=4.50, P<0.05). Conclusion: Cefepime has powerful antibacterial activity against acinetobacter baumannii, escherichia coli and klebsiella pneumoniae. The antibacterial activity of cefepime is lower than that of ceftazidime and piperacillin+tazobactam against pseudomonas aeruginosa.

关 键 词：头孢吡肟 革兰阴性杆菌 体外抗菌活性 儿童 

分 类 号：R978.11[医药卫生—药品]