班布特罗口服液治疗学龄儿童咳嗽变异性哮喘疗效观察  

The curative effect of oral solution of bambuterol hydrochloride on school children with cough variant asthma in 34 children

作　　者：冯梅[1] 

机构地区：[1]浙江省杭州市第一人民医院,浙江杭州310006

出　　处：《儿科药学杂志》2005年第2期26-28,共3页Journal of Pediatric Pharmacy

摘　　要：目的:比较盐酸班布特罗口服液与硫酸特布他林片治疗学龄儿童咳嗽变异性哮喘(CVA)的疗效。方法:学龄儿童CVA64例随机分为二组,A组服班布特罗口服液10mg,每晚1次,B组特布他林片0.0625mg/(kg·次),每日3次口服。治疗前、治疗两周后测定一秒钟用力呼气容积(FEV1)及最大呼气流量(PEF)作为肺功能指标,并作临床评分、生命质量评分作自身对照,并将两组作比较。结果:A、B两组FEV1%、PEF%、生命质量评分均比治疗前升高(P<0.05),且A组PEF%、生命质量评分均高于B组,有显著性差异(P<0.05)。临床评分需吸入β2激动剂次数比治疗前降低,且A组低于B组,有显著性差异(P<0.05)。结论:盐酸班布特罗口服液疗效优于硫酸特布他林片。Objective: The aim of this study was to compare safety and efficacy of bambuterol with terbutaline in school children with cough variant asthma (CVA ). Methods: There were two treatment groups: group A received oral solution of bambuterol hydrochloride (10 mg) administered once a day in the evening and group B received terbutaline sulphate (0.0625 mg/kg body weight) tablets administered three times a day. The study was randomized, and it lasted for 2 weeks after a 2-week run-in period. FEV1 and PEF were checked before and after the treatment for 2 weeks. The clinic symptoms were reported and scored daily. Results: After treatment for 2 weeks,the marks of FEV1% and PEF% and the quality of life in both groups were obviously higher than those before treatment (P < 0.05).The levels of PEF% and the quality of life in group A after treatment were obviously higher than those in group B (P < 0.05). The marks of clinic symptoms in both groups after treatment were obviously lower than those before treatment (P < 0.05). The marks of group A after treatment were obviously lower than those of group B (P < 0.05). Conclusion: It showed a good curative effect in treating CVA in school children with bambuterol or terbutaline, but once-a-day bambuterol is better than terbutaline of three-times-a-day in treating CVA in school children.

关 键 词：学龄儿童 咳嗽变异性哮喘 盐酸班布特罗 硫酸特布他林 

分 类 号：R974.3[医药卫生—药品]