尼莫地平在高血压脑出血术后的降压疗效  

Evaluating efficacy of nimodipine in reducing blood pressure after operation of hypertensive intracerebral hemorrhage

作　　者：张建军[1] 高国梁[1] 董伟峰[1] 严肖峰[1] 

机构地区：[1]萧山市第一人民医院神经外科,浙江杭州311201

出　　处：《中国新药与临床杂志》2005年第5期379-382,共4页Chinese Journal of New Drugs and Clinical Remedies

基　　金：杭州市医学重点专病建设项目([2001]345)

摘　　要：目的:评价尼莫地平在高血压脑出血(HICH)术后出现高血压病人中应用的临床疗效。方法:HICH术后血压高于24.0/14.7kPa的54例病人在常规治疗基础上,分别用尼莫地平(28例)及乌拉地尔(26例)注射液,微泵静脉注射降压,疗程均为7d。观察用药后降压效果及心率变化,经颅彩色多谱勒动态检测患侧大脑中动脉血流改变情况。结果:2药均有明显的降压效果,2组降压过程中对心率影响不大。尼莫地平组和乌拉地尔组7d的脑血管痉挛发生率分别为36%和88%(P<0.01),而7d时脑血管痉挛程度分别为(120±s11)cm·s-1和(146±28)cm·s-1(P<0.01)。结论:尼莫地平能有效控制HICH术后高血压,改善局部脑血流量,提高疗效。AIM: To evaluate the clinical efficacy of nimodipine in the hypertensive intracebral henorrhuge (HICH) whose blood pressure was continously high after operation. METHODS: Fifty-four HICH patients with blood pressure above 24.0/14.7 kPa after operation undergoing conventional therapy,were divided into nimodipine given group 28 patients; and urapidil given group 26 patients for comparing the efficacies in reduction of blood pressure during an egual course of 7 d. The changes of the blood pressure, heart rate and middle cerebral artery blood flow by transcraninal doppler ultrasonography dynamically were observed. The paroxetine was judged by activity daily life after 3 mo. RESULTS: Nimodipine and urapidil could reduce the blood pressure obviously. Both of them showed no adversary effects to the heart rate during the process of reducing the blood pressure. Nimodipine group had less effect on the occurrence of cerebral arterial spasm than that of urapidil group during the 7 d treatment course. CONCLUSION: Nimodipine can control effectively the countious hypertension after operation of HICH, promote regional blood flow with high efficacy and furthermore in preventing cerebral vascular spasm than that of urapidil.

关 键 词：尼莫地平 脑出血 血压 心率 血流动力学 乌拉地尔 

分 类 号：R972.4[医药卫生—药品] R651.12[医药卫生—药学]