近红外荧光散射断层成像的研究进展  

Development of fluorescence optical diffusion tomographyi

作　　者：宋小磊[1] 白净[1] 

机构地区：[1]清华大学生物医学工程系,北京100084

出　　处：《国外医学（生物医学工程分册）》2005年第2期70-75,共6页Foreign Medical Sciences(Biomedical Engineering Fascicle)

基　　金：国家自然科学基金资助项目(60331010);清华大学裕元基金资助项目(202400005-08)

摘　　要：近红外荧光光学断层成像(FODT)是以合适的荧光探针作为标记物或对比剂,用特定波长的红光激发荧光染料,使其发出波长长于激发光的近红外荧光,通过测量媒质边界处有限点的荧光强度,考虑光子在组织中传播的散射特性,来重建出组织内部的荧光光学特性的分布图像以及组织光学参数。这种成像方式具有无电离辐射、染料稳定、可长期监测和设备简单、成本低等优点,在肿瘤检测、基因表达、蛋白质分子检测和药物受体定位等方面有着很大的应用潜力。在给出近红外荧光散射断层成像典型系统的基础上,详述了近红外荧光在组织中的频域传播模型和重建算法;介绍了两家研究机构在此领域的研究进展;讨论了将该成像方法应用于临床的进一步的发展方向。Using appropriate fluorophores probe as indicators or contrast agents with light at its excitation wavelength launched into the tissue and the excited fluorophore emitting light at a longer emission wavelength when it delays to the ground state fluorescence optical diffusion tomography(FODT) measured the emission by an array of detection device. The measured data are then used to reconstruct the distributing image of fluorescence optical charactenistic inside tissue as well as optics parameters. FODT is nonionizing and the agents is stabilized which can be used for long time monitoring with simple and cost effective instrument. It is considered to be a promising tool for tumor detection gene expression profiling protein molecular detection and drug receptor localization. Based on a typical FODT imaging system the frequency domain model describing the propagation of the near infrared fluorescence through tissues and the reconstructed algorithm are presented. Then two institutes' research work is introduced and FODT's development in future is discussed finally.

关 键 词：医学成像 荧光散射断层成像 荧光分子断层成像 

分 类 号：TN219[电子电信—物理电子学]