拉氧头孢对临床分离的1143株致病菌体外抗菌作用的研究  

IN VITRO ACTIVITY OF LATAMOXEF AGAINST 1143 CLINCAL ISOLATES

作　　者：张凤凯[1] 李家泰[1] 潘石[1] 郝凤兰[1] 陈杨[1] 

机构地区：[1]北京医科大学临床药理研究所

出　　处：《中国抗生素杂志》1994年第3期221-229,共9页Chinese Journal of Antibiotics

摘　　要：本文对拉氧头孢的体外活性进行了研究，并与其它β—内酰胺类抗生素的体外活性作比较。结果显示拉氧头孢具广谱抗菌活性且对β—内酰胺酶稳定。拉氧头孢和第三代头孢菌素相似，对许多革兰氏阴性菌有活性，当浓度为０．１２５～４ｍｇ／Ｌ时，能抑制大多数肠杆菌细菌９０％的菌株，和头孢他啶相似，对淋病奈瑟氏球菌和流感嗜血菌有强活性；对假单胞菌的活性逊于头孢他啶，对厌氧菌（如脆弱杆菌）的活性一般强于其它头孢菌素。拉氧头孢对大多数敏感菌的ＭＢＣ等于ＭＩＣ或２ＭＩＣ。对大多数试验菌而言，当接种量增加直到１０６ＣＦＵ／ｍｌ时，对ＭＩＣ的影响小。一般在ｐＨ７．５时对试验菌显示最大抑菌活性。对１１种β—内酰胺酶的相对水解率均为０。The in vitro activivtv of Latamoxef was studied and co-mpared with the activities of other beta- latactam agents.Results showed that it had a broad spectrum of antibacterial activity and was resisant to hydrolysis by beta- lactamases.Like ‘third generation’Cephalosporins,Latamoxef was active in vitro against a wide range of Gram-negative ba-cteria.At concentration of 0.125 to 4 mg/L,it inhibited 90%of strains of most Enferobacteriaceae,Simlar to Ceftazidime,it had stronger activi-ties against Neisseria gonorrhoeae and Haemophilus influenza.The antips-etidomonal activity of Latamoxef was less than that of Ceftazidime.Aga-inst anaerobic bacteria such as Bacteroides fragilis Latamoxef generally had activity greater than that of other Cephalosporins,Against most susce-ptible bacteria,the minimum bactericidal concentration(MBC)of Lat-maoxef is equalto or twice the minimum inhibitory concentration(MIC).The MIC of Latamoxef for most strains tested was little affected by incr-eases in inoculum size up to 106 CFU/ml,Generally,a pH of 7.5appeared to be optimal for inhibitory activity against the tested isolates,The rela-tive hydrolysis rate of 11 beta- lactamases against Latamoxef were zero.

关 键 词：拉氧头孢 体外 抗菌活性 致病菌 

分 类 号：R978.11[医药卫生—药品]