泰宁等7种抗菌药物对临床常见致病菌抗菌活性的比较  

COMPARISION OF ANTIBACTERIAL ACTIVITY OF IMP/CS AND OTHER 6 ANTIMICROBIAL AGENTS AGAINST CLINICAL ISOLATES

作　　者：王睿[1] 陈迁[1] 陈孟莉[1] 吴坚[1] 祝勇梅 刘桂兰[1] 

机构地区：[1]中国人民解放军总医院临床药理研究室

出　　处：《中国抗生素杂志》1994年第5期356-362,共7页Chinese Journal of Antibiotics

摘　　要：用琼脂平板稀释法测定泰宁等７种抗菌药物对５种２１５株临床常见致病菌的最低抑菌浓度（ＭＩＣ），井统计敏感率。结果表明７种抗菌药物对大多数受试菌均显示较高的抗菌活性，其中泰宁的抗菌活性最强。金葡球菌、变形杆菌、大肠埃希氏菌、肺炎克雷白氏菌对泰宁的敏感率达９７．６～１００％；绿脓假单胞菌１７．０２％耐药，绿脓假单胞菌４．２６～１２．７７％和肺炎克雷白氏菌１株对泰宁和其他抗菌药物呈现部分交叉耐药性，而ＣＰＬＸ与其他抗菌药物对不同受试菌呈现２．３８～１９．０５％的交叉耐药率。该结果提示对其他β－内酰胺类抗菌药物耐药的致病引起的严重感染，可考虑选用泰宁，但ＣＰＬＸ的选用还应根据药敏试验决定。The minimum inhibitory concentration(MIC)of 7 anti-microbial agents against 215 strains of 5 species of clinical isolates were determined by using agar disk dilutlon method and the susceptible rates were analyzed. Results showed that all 7 antimicrobial agents exhibited high activity against most of isolates tested. Among them the IMP/CS had the strongest activity;the susceptible rates agaInst S. aureus, Proteus sp,E.coli,K. pneulnoniae to the IMP/CS were high up to 97.6～100%;only 17.02% stra-ins of Ps. aeruginosa were resistant to IMP/CS; 2～6 strains of Ps.aeru-ginosa and 1 strains of K. pneumoniae were crossresistant to IMP/CS and other antimicrobial agents.The crossresistant rates of the isolates testedto CPLX and other antimicrobial agents were 2.38～19.05%.The results suggested that IMP/CS may be used in treatment of ser-ious infections caused by clinical isolates resistant to other β-lactam antimicrobial agents; the CPLX should be selected according to the susc-eptibility test.

关 键 词：泰宁 最低抑菌浓度 交叉耐药性 环丙沙星 

分 类 号：R978.19[医药卫生—药品] R915[医药卫生—药学]