茯苓素诱生肿瘤坏死因子（TNF）的作用  

POTENTIATION OF INDUCTIVE SECRETION OF TUMOR NECROSIS FACTOR BY PORIATIN

作　　者：周立[1] 张玮[1] 蔺惠颜 许津[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所

出　　处：《中国抗生素杂志》1994年第5期376-380,共5页Chinese Journal of Antibiotics

基　　金：医科院院校基金

摘　　要：本文报道茯苓素在小鼠体内、外诱生肿瘤坏死因子的作用。实验表明：茯苓素小鼠体内、外能明显增强经ＢＣＧ预先激活的巨噬细胞产生ＴＮＦ的能力，且有显著的剂量依赖性关系。茯苓素在体内对小鼠移植性肿瘤Ｓ－１８０细胞有明显的抑制生长作用，其作用强弱与ＴＮＦ的水平呈正相关。诱生出的ＴＮＦ可通过抗体中和实验得到确证。In this paper it is reported that poriatin increased the se-crpMtion of TNF by macrophages both in vitro and in vivo on mice.The experi-ment showed that the ability of releasing TNF by macrophages that had been pre-actived by BCG were enhanced obviously and dose-depndently. The growth of Sarcoma 180 in mice can be markedly inhibited by poriatin vivo and the degree of the inhibition was closely related to the level of TNF in serum.The level,of TNF was demonstrated by antibody ne-utralizing test.

关 键 词：茯苓素 肿瘤坏死因子 巨噬细胞 肉瘤S-180细胞 

分 类 号：R979.5[医药卫生—药品] R73－36[医药卫生—药学]