^(99)mTc水杨醛Schiff碱配合物的制备与生物分布  

Synthesis and Biodistribution of ()^(99m)Tc Salicylidene Schiff Base Complex

作　　者：王明召[1] 孟昭兴[1] 彭安[2] 谭信[3] 

机构地区：[1]放射性药物教育部重点实验室,北京师范大学化学系,北京100875 [2]北京师范大学生命科学学院,北京100875 [3]北京理工大学生命科学与技术学院,北京100081

出　　处：《高等学校化学学报》2005年第5期816-818,F011,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:30270661);放射性药物教育部重点实验室基金资助.

摘　　要：One novel complex of （）99mTc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-（isomers） might co-exist in aqueous solution. A yield higher than 90% under the optimal condition of synthesis was obtained. Good water-solubility was demonstrated. Very little uptakes in muscle, brain, heart and S-180 sarcoma, as well as very rapid blood clearance were revealed in mice. Good accumulation in bone was shown. At 1 h postinjection the bone uptake was 10.9%ID/g. At 3 and 5 h postinjection, bone-to-muscle ratios were 19.0 and 9.3, and bone-to-blood ratios were 31.6 and 28.9, respectively. The result indicates a bone imaging potency of the complex.One novel complex of ()^(99m)Tc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-(isomers) might co-exist in aqueous solution. A yield higher than 90% under the optimal condition of synthesis was obtained. Good water-solubility was demonstrated. Very little uptakes in muscle, brain, heart and S-180 sarcoma, as well as very rapid blood clearance were revealed in mice. Good accumulation in bone was shown. At 1 h postinjection the bone uptake was 10.9%ID/g. At 3 and 5 h postinjection, bone-to-muscle ratios were 19.0 and 9.3, and bone-to-blood ratios were 31.6 and 28.9, respectively. The result indicates a bone imaging potency of the complex.

关 键 词：^99MTC 水杨醛酪氨酸Schiff碱配合物 合成 生物分布 

分 类 号：O614.5[理学—无机化学]