Simulation Analysis of Dilution Crystallization of Spectinomycin Dihydrochloride Pentahydrate  

作　　者：鲍颖 王静康 王永莉 

机构地区：[1]School of Chemical Engineering and Technology Tianjin University, Tianjin 300072,China,Post-Doctoral Station of Tianjin Economic and Technological Development Area, Tianjin 300457,China [2]School of Chemical Engineering and Technology Tianjin University, Tianjin 300072, China

出　　处：《Chinese Journal of Chemical Engineering》2005年第2期191-196,共6页中国化学工程学报（英文版）

摘　　要：A mathematical model for dilution crystallization of spectinomycin dihydrochloride pentahydrate was established on the basis of the population and mass balance. Three operating modes, i.e., constant mass rate addition of diluent, constant mass fraction of diluent and constant size-independent growth rate, were investigated over a wide range of controlled parameters. The intrinsic characteristics of the crystallization process and the influence of operation parameters were analyzed in detail. Suitable strategy for better performance was suggested.A mathematical model for dilution crystallization of spectinomycin dihydrochloride pentahydrate was established on the basis of the population and mass balance. Three operating modes, i.e., constant mass rate addition of diluent, constant mass fraction of diluent and constant size-independent growth rate, were investigated over a wide range of controlled parameters. The intrinsic characteristics of the crystallization process and the influence of operation parameters were analyzed in detail. Suitable strategy for better performance was suggested.

关 键 词：spectinomycin dihydrochloride pentahydrate dilution crystallization mathematical model 

分 类 号：TQ465[化学工程—制药化工]