SansalvamideA固相合成新方法  

Novel Solid-phase Synthetic Method of Sansalvamide A

作　　者：刘守信[1] 冯霄[1] 耿艳楼[2] 姚军[2] 李军章[2] 

机构地区：[1]西安交通大学环境与化学工程学院,西安710049 [2]河北科技大学化学与制药工程学院,石家庄050018

出　　处：《有机化学》2005年第5期604-607,i005,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.30472074)资助项目

摘　　要：报道了Pd催化丁基二乙基硅烷树脂与N-Boc-4-溴代苯丙氨酸甲酯直接反应形成Si—Ar键一步构建出硅基连接分子的新方法,并采用Boc策略增长肽链,以PyBOP(benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphoniumhexafluoro-phosphate)为环合剂固相合成了sansalvamideA.It was reported that butyldiethylsilane polystyrene reacted with N-Boc-4-bromophenylalanine under palladium catalyzation to directly form silicon-linker with silicon aryl carbon bond. The peptide chain was elongated by using Boc strategy. And sansalvamide A was obtained by solid phase synthesis using Py- BOP (benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate) as cyclization reagent.

关 键 词：固相合成方法 硅基连接分子 PD催化剂 环肽类化合物 丁基二乙基硅烷树脂 抗肿瘤药物 

分 类 号：TQ464.7[化学工程—制药化工]