利培酮的电化学行为及应用研究  

Investigation on Electrochemical Behavior of Risperidone and Its Application

作　　者：孟祖超[1] 郑建斌[1] 朱小红[1] 

机构地区：[1]西北大学分析科学研究所陕西省电分析化学重点实验室,西安710069

出　　处：《化学学报》2005年第9期827-833,i002,共8页Acta Chimica Sinica

基　　金：国家自然科学基金(No.20275030);陕西省自然科学基金(No.2004B20);西北大学校内基金;西北大学重点科研基地开放课题基金资助项目

摘　　要：采用循环伏安法、线性扫描伏安法、常规脉冲伏安法和恒电位电解法等电化学手段,详细研究了利培酮在pH7.07～10.32B-R缓冲溶液和0.2mol?L-1NaOH溶液中的电化学行为.研究表明:在pH7.07～10.07B-R缓冲溶液中,利培酮产生的P1波为催化氢波.在pH=10.32B-R缓冲溶液中,利培酮可以产生P2和P3两个波.其中,P2波为不可逆的单电子还原波,P3波可以分裂成两个波P3a和P3b.P3a波为P2波的进一步单电子还原,而P3b波则属于催化氢波.在0.2mol?L-1NaOH溶液中,利培酮产生的P4波是一个两电子的不可逆还原波.另外,根据P1波的一阶导数峰电流与利培酮浓度在1.6×10-5～2.0×10-6mol?L-1(r=0.9950)间的线性关系,建立了利培酮片剂中利培酮含量的测定新方法.新方法的检出限为1.0×10-6mol?L-1,回收率在105%～102%之间,相对标准偏差为0.84%.The electrochemical behavior of risperidone was studied in pH 7.07 similar to 10.32 B-R buffer solutions and 0.2 mol center dot L-1 NaOH solution by means of cyclic voltammetry, linear sweep voltammetry, normal pulse voltammetry and controlled-potential electrolysis. Risperidone yielded one wave P, as pH of B-R buffer solution was changed from 7.07 up to 10.07, which was a catalytic hydrogen wave. Additional two waves P-2 and P-3 were exhibited in pH= 10.32 B-R buffer solution. P-2 wave was an irreversible adsorption reduction wave involving one electron. P-3 could be split into P-3a and P-3b. Of them, P-3a was the further reduction wave Of P2, and P3b was a catalytic hydrogen wave. Otherwise, based on the linear relation between the first-order derivative peak current of P, and the concentration of risperidone in the range of 1.6 X 10(-5)similar to 2.0 X 10(-6) mol center dot L-1 with a 0.995 Correlation coefficient, a new method for determination of risperidone in risperidone tablets was described. The detection limit was 1.0 X 10(-6) mol center dot L-1, and the recovery of risperidone was between 105% and 102% with a relative standard deviation of 0.84%.

关 键 词：电化学行为 利培酮 NAOH溶液 线性扫描伏安法 单电子还原 应用 缓冲溶液 催化氢波 循环伏安法 脉冲伏安法 化学手段 一阶导数 线性关系 不可逆 电解法 恒电位 峰电流 mol 检出限 回收率 分裂 

分 类 号：TQ463[化学工程—制药化工]