糖耐量受损者胰岛素敏感性及胰岛β细胞功能的研究  

Insulin resistance and beta-cell dysfunction in Shengyang subjects with impaired glucose tolerance

作　　者：李玲[1] 厉平[1] 王贵新[2] 姜甲军 刘秀明[4] 尚小静[1] 

机构地区：[1]中国医科大学第二临床学院内分泌科,沈阳10004 [2]中国医科大学第二临床学院检验科,沈阳10004 [3]丹东市慢性病研究所 [4]中国医科大学第一临床学院中医科

出　　处：《中华糖尿病杂志（1006-6187）》2005年第2期87-89,共3页

摘　　要：目的　研究糖耐量受损(IGT)者的胰岛素抵抗(IR)及胰岛β细胞功能变化。　方法　选取正常糖耐量(NGT)、IGT、2型糖尿病(T2DM)者共34 例,以高胰岛素正血糖钳夹技术测定IR,行静脉葡萄糖耐量试验评估胰岛β细胞分泌功能。　结果　与NGT组相比,IGT组、T2DM组的IR显著升高;IGT组胰岛素第一时相分泌明显下降,空腹胰岛素(FIns)水平及第二时相分泌水平升高;T2DM组IR与IGT组处于同一水平,FIns较NGT组显著减少。　结论　由NGT向IGT的演变过程中,IR和胰岛素分泌缺陷共同起作用。Objective To study insulin resistance and beta-cell function of Shenyang subjects with impaired glucose tolerance (IGT) and to investigate the pathogenesis of type 2 diabetes mellitus (T2DM). Methods We performed the study in a total of 34 subjects with varying degree of glucose tolerance (12 subjects with normal glucose tolerance (NGT), 14 with IGT, and 8 with DM). Insulin resistance was measured using hyperinsulin-euglycemic clamp, and beta-cell function was assessed by intraveneous glucose tolerance test. Results Compared with the NGT group, the subjects with IGT had significantly lower glucose infusion rate (GIR, mg·kg^(-1)·min^(-1)) (5.1±0.6 vs 10.1±1.0, P<0.01), significantly increased fasting plasma insulin level (28.1±3.4 vs 12.6±1.1 mU/L, P<0.01), markedly reduced first-phase insulin secretion (11.3±2.9 vs 43.0±9.6 mU/L, P<0.01) and markedly elevated second-phase insulin secretion (35.3±7.3 vs 15.3±2.0 mU/L,P<0.01). The GIR in the subjects with DM was as great as that in those with IGT (4.5±0.4 vs 5.1±0.6, P=0.53 ), but fasting plasma insulin level in the DM group was significantly lower than that in the IGT group(13.9±1.1 vs 28.1±3.4 mU/L, P<0.01). Conclusion Both insulin resistance and insulin secretion dysfunction are associated with the transition from NGT to IGT in Chinese northeast (subjects.)

关 键 词：糖耐量 胰岛素 敏感性 胰岛Β细胞 细胞功能 葡萄糖钳夹技术 

分 类 号：R587.1[医药卫生—内分泌]