ICAM-1/LFA-1在结肠癌淋巴转移中表达的研究  

Expression of Intercellular Adhesion Molecule-land Lymphocyte Function Association Antigen-1 in Lymphatic Metastasis of Colon Cancer and its Clinical Significance.Zheng Hui.Department of Anatomy

作　　者：郑辉[1] 张雅芳[2] 

机构地区：[1]黑龙江省齐齐哈尔医学院解剖教研室,161042 [2]哈尔滨医科大学解剖教研室,150086

出　　处：《医学研究通讯》2005年第5期20-22,共3页Bulletin of Medical Research

摘　　要：目的研究结肠癌瘤体细胞间粘附分子-1(intercellular adhesion molecule-1,ICAM-1)和淋巴细胞功能相关抗原-1(lymphocyte function association antigen-1,LFA-1)的表达与结肠癌临床病理特征及其侵袭转移的关系。方法采用免疫组化技术(S-P 法)对60例结肠癌及15例远癌结肠组织标本中 ICAM-1和 LFA-1进行检测,分析 ICAM-1和 LFA-1的表达与结肠癌临床病理之间的关系。结果结肠癌和远癌结肠组织中 ICAM-1的阳性表达率分别为70%(42/60)和20%(3/15),两者之间差异有显著性(P<0.01),LFA-1的阳性表达率分别为68.3%(41/60)和13.3%(2/15),两者之间差异有显著性(P<0.01),组织 ICAM-1和 LFA-1表达水平与结肠癌淋巴结转移、TNM 分期密切相关。结论检测结肠癌组织 ICAM-1的表达水平对评估淋巴结转移程度、TNM 分期及结肠癌侵袭深度有较大意义,ICAM-1可能是反映结肠癌侵袭转移潜能的一个有效生物学指标。Objective This study was to determine the expression of ICAM-1(intercellular adhesion molecule-1)and LFA-1(lym- phocyte function association antigen-1)in patients with colon cancer and to elucidate the relation of its level with clinical characteristics and metastasis of colon cancer. Methods Immunohistochemical method was used to detect ICAM-1 and LFA-1 expression in 60 patients with colon cancer and in 15 cases of colon tissue distal to cancer cell. Results The positive expression rates of ICAM-1 in culoncancer and colon tissue distal to cancer cell were 70%(42/60)and 20%(3/15)respectively, with significant difference(P<0.01), The positive expression rates of LFA-1 in coloncancer and colon tissue distal to cancer cell were 68.3%(41/60)and 13.3%(2/15)respectively, with significant differ- ence(P<0.01), The intensity of ICAM-1 and LFA-1 expression in tissue of colon cancer was correlated with lymph node metastasis and TNM stage. Conclusion Examination of ICAM-1 and LFA-1 in colon cancer helps evaluation intensity of lymph node metastasis, TNM stage and prognosis of patients. ICAM-1 and LFA-1 might bevaluable markers in assessing invasion and metastasis potential of colon carcinoma.

关 键 词：ICAM-1/LFA-1 表达的研究 淋巴转移 淋巴细胞功能相关抗原 function 细胞间粘附分子 临床病理特征及 LFA-1表达 淋巴结转移程度 阳性表达率 TNM分期 免疫组化技术 结肠癌组织 生物学指标 侵袭转移 组织标本 S-P法 结肠组织 

分 类 号：R392.12[医药卫生—免疫学] R457.7[医药卫生—基础医学]