单纯疱疹病毒感染与冠心病急性心肌梗死相关性研究  

Relationship between Herpes simplex virus infection and acute myocardial infarction

作　　者：刘大男[1] 李金生[2] 何作云[1] 

机构地区：[1]第三军医大学新桥医院心内科 [2]贵阳医学院附属医院心内科,550004

出　　处：《中国实用内科杂志》2005年第5期425-427,共3页Chinese Journal of Practical Internal Medicine

基　　金：贵州省科学基金资助项目(黔科合字19991177号)

摘　　要：目的探讨单纯疱疹病毒(HSV)感染与冠心病心肌梗死的关系。方法测定51例急性心肌梗死(AMI)和42例陈旧性心肌梗死(OMI)患者及31例冠脉造影正常者(NC)的HSV1抗体水平及脱氧核糖核酸(DNA),同时观测纤维蛋白原(Fg)、6酮前列环素F1α(6Keto PGF1a)、血栓素B2(TXB2)、P选择素(GMP140)变化。结果AMI组HSV1免疫球蛋白G(IgG)阳性率及水平高于NC组(P<0.05),HSV1DNA检测结果与之吻合。校正冠心病危险因素前、后,HSV1IgG阳性与AMI均有相关关系(OR4.266,P=0.019;OR3.321,P=0.032)。AMI组中HSV1(+)组Fg、TXB2、GMP140高于,而6Keto PGF1a低于HSV1(-)组(P均<0.05);并且IgG与TXB2、GMP140呈正相关,与6Keto PGF1a呈负相关,调整冠心病的危险因素前、后,IgG与Fg均呈正相关。结论HSV1感染与AMI之间存在明显的相关性,与Fg、TXB、6-Keto-PGF及GMP也存在相关性。ObjectiveTo investigate the correlations between Herpes simplex virus (HSV) infection and acute myocardial infarction(AMI).MethodsSpecific antibodies and DNA to HSV-1 were measured in 51 patients with AMI(AMI group),42 patients with old myocardial infarction (OMI group) and 31 normal controls (NC group) who had no angiographic evidence of coronary artery disease.Moreover,the changes of and relationships between fibrinogen(Fg),6-Keto-prostaglandin-F 1α (6-Keto-PGF 1α ),Thromboxane B 2 (TXB 2 ),P-selection(GMP 140 ) and HSV-1 infection were determined in the three groups.ResultsThe prevalence of HSV-1IgG antibody was associated with AMI(OR4.266).Adjustment for the major cardiovascular risk factors didn't attenuate this correlation(OR3.321).Those who were HSV-1 positive in the AMI group had significantly higher levels of Fg,TXB 2 and GMP 140 and a significantly lower level of 6-Keto-PGF 1α than those who were HSV-1 negative in the same group.Correlation analysis revealed that the average concentration of IgG antibody to HSV-1 was positively associated with the levels of Fg,TXB 2 and GMP 140 but negatively associated with the level of 6-Keto-PGF 1α in the HSV-1 positive patients of the AMI group.ConclusionThere is a significant correlation between HSV-1 infection and AMI.HSV-1 infection is associated with Fg,TXB 2 ,6-Keto-PGF 1α and GMP 140 .

关 键 词：急性心肌梗死 单纯疱疹病毒 纤维蛋白原 血栓素B2 6-酮-前列环素F1a P-选择素 

分 类 号：R542.22[医药卫生—心血管疾病]