阿奇红霉素与罗红霉素随机对照治疗30对细菌性感染的临床评价  

A RANDOMIZED CONTROLLED CLINICAL TRIAL OF AZITHROMYCIN IN THE TREATMENT OF BACTERIAL INFECTIONS

作　　者：侯芳[1] 崔洪[1] 郝凤兰[1] 李天云[1] 李家泰[1] 

机构地区：[1]北京医科大学临床药理研究所抗感染研究室,北京100034

出　　处：《中国临床药理学杂志》1994年第3期129-135,共7页The Chinese Journal of Clinical Pharmacology

摘　　要：阿奇红霉素为一新的azalide类抗生素,为评价其安全性及有效性,我们以罗红霉素为对照药,进行随机对照试验治疗细菌性感染60例,阿奇红霉素组30例,剂量第一日500mg,以后4日250 mg,每日一次;罗红霉素组30例,第一日300mg bid,以后4日150 mgbid,疗程均为5d.两组痊愈显效率分别为93.3%及90.0%,细菌清除率分别为93.3%及86.7%,不良反应发生率均为10.0%.以上结果经统计学处理无显著性差异.Azithromycin is a new azalide antibiotic. A randomized controlled clinical trial wasconducted to evaluate the efficacy and safety of azithromycin in comparison with roxithromycin in the treatment of 60 cases of bacterial infection. 30 patients were administered azithromycin once daily at the dosage of 500 mg on day 1 and 250 mg on day 2-5 each, The other 30 patients received roxithromycin at 300 mg bid on day 1 and 150 mg bid on day 2 - 5 each. So, the duration of treatment of either group was 5 days. The results showed that the overall clinical efficacy rates of azithromycin and roxithromycin were 93.3% and 90.0% respectively, and the bacterial clearance rates were 93.3% and 86.7% respectively. The incidence of adverse drug reaction of both groups was 10. 0% . These results indicated that there was no statistical difference in the clinical efficacy, bacterial clearance and adverse drug reaction between the two groups.

关 键 词：阿奇红霉素 罗红霉素 随机对照试验 细菌性感染 

分 类 号：R978.15[医药卫生—药品]