犰狳感染麻风加化疗其眼的组织学研究  

Histologic Study of the Eyes of Armadillos Experimentally Infected with M. Leprae before and after Chemotherapy

作　　者：周惠民[1] 武惠[1] 石珍荣[1] Kazda J Brandt F 

机构地区：[1]青岛医学院,青岛市江苏路16号266003 [2]德国

出　　处：《中国麻风杂志》1994年第2期73-76,共4页

摘　　要：穆斯堡尔效应是现代物理学中最重要的发现之一，３０多年来该效应的应用在物理、化学、生物、冶金等现代科技领域中已取得惊人的发展和出成就。本文对此做发简要阐述。Twenty four armadillos were inoculated with M.leprae.Eleven months after the inoculation,the right eyes of the animals were extracted.The animals then were divided into two groups for treatment,one group with MDT and the other with DDS.Two months later the animals were sacrificed.The histological changes of their eyes,the lepromas at the sites of the inoculation and the viscera were studied.It was found that the contents of the bacilli in the nver or spleen of the animals in both the groups,were similar.It seems that the sizes of the lepromas before and after treatment were of no statistically significant difference.The inflammatory reaction of the nictating membranes and eyelids in eight animals were quite severe,and lepra cell infiltration and acid fast bacilli were found in these tissues of four animals.Intraocular inflammatory cell trifiltrations in these animals all were mild,and no acid fast bacilli was found within the eyes,except in one.In view of these findings,it might be suggestive that some intraocular leprosy could be the result of spreading of infection from the lesions of the periocular tissues.If so,local drug treatment in the eye in addition to the general treatment in the patients would be useful in preventing or minimizing the intraocular lesions.

关 键 词：麻风 药物疗法 眼 犰狳 

分 类 号：R755.02[医药卫生—皮肤病学与性病学]