冠心病遗传度和家族集聚性研究  

THE STUDY ON HERI TABILITY AND FAMIL-IAL AGGREGATION OF CORONARY HEART DISEASE

作　　者：王敏霓[1] 

机构地区：[1]广州暨南大学医学院

出　　处：《中国慢性病预防与控制》1994年第5期197-198,220,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：本文就广州高等学校知识分于中作了冠心病遗传流行病学研究，发现冠心病先证者的一级亲属冠心病患病率为７．０３％，远比对照组一级亲属的患病率２．６４％高，约为２．６倍；以二项分布数学模式拟合，发现冠心病例分布皇家族聚集现象；用Ｌｉｍｅｎｔｅｌ－Ｇａｒｔ法计算其分离比为０．０４；以Ｆａｌｃｏｎｅｒ氏阈值法估算，冠心病的遗传度为３８．９％，根据所获指标及特点，提示冠心病系多基因遗传性疾病。强调今后应进一步广泛开拓宏观流行病学研究，并结合微观分子水平的分析，对阐明冠心病病因和发病机理，以及有效防治极为重要。he strdy of genetic epidemiology of CHD anong the senior intellectuals of the universities in Guangzhou was carried out.It revealed that the prevalence of CHD in the first degree relatives of the CHD group was 7. 03%which was much higher than that of the control group(2. 64%).Thecase distribution of CHD presented the phenornenon of familial aggregation with the fitting of the binomial distr-bution. By the m ethod of Limentel一Gart the separate ratio was 0.04.The heritability of CHD was 38.9%by using Fal coner′s Threshold Calculation。 Owing to the lack of her-itability value of CHD in China ,the result in lhis paper can be a useful refcrence. A ccording to the indexes and charac-ter obtained from the survey , it suggested that CHD may be a polygenlc desease.

关 键 词：家族聚集性 遗传 冠心病 

分 类 号：R541.402[医药卫生—心血管疾病]