可溶性白介素2受体测定对结核性胸腹水鉴别诊断的价值  

THE DIFFREENTIAL DIAGNOSTIC EVALUE OF DETERMINA-TION OF SOLUBLE INTERLUBLE INTERLEUKIN-2 RECPTORS IN TUBERCU-LOUS PLEUROPERITONEAL EFFUSIONS

作　　者：李凤山[1] 高振耀 杜新生[1] 李玉柱[1] 张秀芹[1] 张敏[1] 马淑清[1] 郭连兴[1] 

机构地区：[1]承德医学院附属医院内二科,承德医学院附属医院检验科

出　　处：《中国免疫学杂志》1994年第3期182-185,共4页Chinese Journal of Immunology

摘　　要：用ＥＬＩＳＡ方法检测结核性和非结核性（癌性及漏出液）胸水及血清中的可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）。结果显示：结核组ｓＩＬ－２Ｒ水平明显增高（２４６４±１００１Ｕ／ｍｌ），与癌性胸腹水组（７５２±４１８Ｕ／ｍｌ）及漏出液组（４１０±３１５Ｕ／ｍｌ）比较有显著性差异（Ｐ＜０．００１）。与胸水中腺苷脱氨酶活性（ＡＤＡ）呈正相关（ｒ＝０．６８８，Ｐ＜０．００１）。敏感性及特异性均为９０％以上。提示用本法检测胸腹水的ｓＩＬ－２Ｒ对于结核性胸腹水的诊断及鉴别诊断有重要意义。he levels of soluble IL-2R were determined in pleural fluid and serum from 30 patientswith tuberculous pleurisy and 57 nontuberculous(30 cases of malignant,27 cases of transudative,There were significantly elevated soluble IL-2R values in tuberculous pleural fluid(2464±1001U/ml)as compared with pleuroperitoneal fluid of nontuberculous etiology including malig-nant(752± 418U/ml)and transudative(4l0± 315U/ml)effusions.In patients with tubercu-lous pleurisy,the level of soluble IL-2R in pleural fluid was markedly greater than that inserum.A significant positive correlation was observed between soluble IL-2R levels and adeno-sine deaminase levels in tuberculous pleural fluid.Fixing the cut off points of soluble IL-2R val-ues at 1500U or l000U the tuberculous pleural effusion cases were differentiated from the non-tuberculous with a sensitivity、specificity、postive predictive value、negative predictive value andaccuracy of over 90 percent.

关 键 词：胸腔积液 白细胞介素2 结核性 

分 类 号：R521.704[医药卫生—内科学]