流行性出血热病人IgE与IgE－CIC产生动态及影响CIC沉积和排除的因素  

PRODUCTION KINETICS OF IGE AND IMMUNE COMPLEX OFIGE IH EHF PATIENTS AND THE FACTORS AFFECTING IM-MUNE COMPLEX DEPOSITION

作　　者：王文余[1] 张凤蕴[1] 赵育莹[1] 常金兰[1] 

机构地区：[1]哈尔滨医科大学免疫学教研室

出　　处：《中国免疫学杂志》1994年第4期251-253,共3页Chinese Journal of Immunology

摘　　要：应用双抗体夹心法和ＰＥＧ沉淀－ＥＬＩＳＡ双抗体夹心法分别检测了ＥＨＦ病人血清中ＩｇＥ和ＩｇＥ－ＣＩＣ产生的动态水平。检测结果发现ＩｇＥ水平于发病３～５天达高峰ＩｇＥ－ＣＩＣ于发病６～１０天达高峰，此时机体ＲＢＣ排除ＣＩＣ及补体溶解ＩＣ活性（ＣＲＡ）功能低下，随着排除ＣＣ功能的恢复，ＣＩＣ减少。如往病人血清中加入含补体血清时，ＣＩＣ被溶解，ＣＩＣ水平下降，提示给病人输注大量新鲜含补体血浆可达治疗的目的。he serum IgE and immune complex of IgE in the EHF patients were determinted withELISA(double antibody method)and the deposited immune complex of IgE in the cadaviric kid-ney was examined with immunoenzymatic-histochemical method. The highest level of IgE andimmune complex of IgE were found on the day 3 to 5 and 6 to 10 in the disease courses respec-tively. when RBC immune function declined and it was unable to climinate immune complex andunder the condition of lower CRA. The immune complex precipitated in kidney and led to thedamage of it. Our experiment results also showed that the CIC in sera of EHF patients decreasedmarkedly after adding fresh plasma to the sera of patient.It is suggested that fresh plasma canbe valuable to treat EHF patients by means of enhancing CRA function.

关 键 词：流行性出血热 补体 免疫球蛋白E 

分 类 号：R512.803[医药卫生—内科学]