不同年龄大鼠胸腺及脾脏P物质含量的变化及其意义初探  

VARIATON OF SUBSTANCE P CONTENT IN RAT THY-MUS AND SPLEEN AGES AND THE PRELIMINARYSTUDY OF ITS SIGNIFICANCE

作　　者：朱高发 陈娟[1] 刘燕[1] 张凯 张艳萍[1] 徐承焘[1] 

机构地区：[1]中国医学科学院基础医学研究所

出　　处：《中国免疫学杂志》1994年第5期270-273,共4页Chinese Journal of Immunology

基　　金：国家自然科学基金

摘　　要：实验以放射免疫测定法分别观在了５天、１５天及１、２、３、４、６，１２个月不同年龄组大鼠胸腺及脾脏Ｐ物质（ＳＰ）含量的变化，同时观察了成年大鼠皮下注射（ｓ．ｃ）辣椒素（Ｃａｐ）及新生大巴ｓ．ｃ．ＳＰ抗血清对大鼠胸腺和脾腺ＳＰ含量的影响。结果表明：胸腺及脾脏这两大重要免疫器官中均有ＳＰ存在；胸腺中ＳＰ含量与胸腺的重量呈显著的负相关，脾脏中也有类似的现象，但不如胸腺显著。此外不管是胸腺还是脾脏其中的ＳＰ外均不能为Ｃａｐ耗竭，可能不是来源于无髓的感觉神经末梢；幼年期改变动物的ＳＰ水平可以影响成年后胸腺的重量，即ＳＰ可能与胸腺发育及退化有关；ＳＰ对脾脏的发育可能影响不大。he variation of substance P(SP)content in rat thymus and spleen with different ages(5,15 days,1,2,3,4,6 and 12 months)was investigated by radioimmunoassay.Meanwhile,the ef-fects of subcutaneous injection(s.c. )of capsaicin(Cap)and SP antiserum on SP contents in ratthymus and spleen were also studied. The results show that after birth thymic weight increasedgradually until 2 months of age,then diminished progressively. SP content in thymus decreasedgradually from birth to 2 months of age,then followed by a progressive increase and was nega-tively interrelated with thymic weight.There was similar behavior in spleen. SP in the two or-gans can not be depleted by Cap and suggest that it might not originate from the Sp-containingprimary sensory fibers.Changing the SP level of thymic as neonates may affect the thymicweight in adult.And SP might relate to the development and involution of thymus.

关 键 词：胸腺 脾脏 P物质 

分 类 号：R392.11[医药卫生—免疫学]