白细胞介素-1与原发性肾病综合征的关系  

Relationship between Interleukin - 1 Level of Serum and Primary Nephrotic Syndrome in Children

作　　者：向龙[1] 付雪梅[2] 卓平辉[2] 毛萌[2] 杨涛[1] 王伟光[1] 周斌[1] 

机构地区：[1]广东省妇幼保健院广东省妇女儿童医院,广州510010 [2]四川大学华西第二医院儿科,成都610041

出　　处：《实用儿科临床杂志》2005年第5期410-411,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨白细胞介素-1(IL—1)与原发性肾病综合征(PNS)间的关系。方法采用ELISA法测定PNS患儿急性期和缓解期血清IL-1水平,分析与24 h尿蛋白定量间的关系。结果PNS患儿急性期和缓解期血清IL-1水平比较有显著差异(P<0.01),急性期肾炎型肾病组(NN)血清IL—1高于单纯型肾病组(SN)(P<0.01)。PNS血清IL-1水平与24 h尿蛋白排泄量间呈明显正相关(r=0 758 P<0.01)。结论PNS患儿血清IL-1水平是升高的,IL-1可能在PNS发病中起部分作用。Objective To investigate the relationship between interleukin-1 (IL-1) and pathogenesis of primary nephrotic syndrome (PNS) in children. Methods IL-1 level of serum was measured by enzyme-linked immunosorbent assay(ELISA) in children with PNS who were in active and stable phase and the correlations between IL-1 and urinary protein in 24 hours were analyzed respectively. Results IL-1 level of serum in active phase was significantly higher than that in the stable phase in children with PNS(P< 0.01). IL-1 level of serum in the active phase in NN was significantly higher than that of the stable phase in SN There was a positive correlation between IL-1 level of serum and the excretion of urinary protein in 24 hours( r = 0. 758 P<0.01) Conclusions The IL-1 level in serum is increased in PNS children. IL-1 may play a partial role in the pathogenesis of PNS.

关 键 词：白细胞介素-1 肾变病综合征 原发性 儿童 

分 类 号：R726.91[医药卫生—儿科]