望春花油的抗炎机理  

Anti-inflammatory Mechanism of the Volatile Oil of Magnolia biondii Pamp.

作　　者：王文魁[1] 沈映君[2] 齐云[3] 刘晋平[1] 宋金香[1] 

机构地区：[1]山西农业大学动物科技学院,山西太谷030801 [2]成都中医药大学药学院,四川成都610075 [3]中国医学科学院协和医科大学药用植物研究所,北京100094

出　　处：《中国兽医学报》2005年第3期301-303,共3页Chinese Journal of Veterinary Science

摘　　要：为探讨望春花挥发油的抗炎机理,向去肾上腺大鼠的胸膜腔及右后足皮下分别注射1%角叉菜胶及10%蛋清溶液,诱发胸膜炎及足肿胀炎症模型。结果显示,事先灌服望春花挥发油的试验组大鼠,其炎症表现显著轻于对照组,其炎症介质TNF、组织胺和PGE2的产生显著少于对照组,炎症相关酶PLA2的活性显著低于对照组。由此表明,望春花油的抗炎效应不依赖于下丘脑-垂体-肾上腺轴,而是直接阻抑炎症介质的产生。Wistar Rats were adrenalectomized.7 days later,1% carrageenan was injected into the rats′ thoracic cavity,and 10% egg-white subcutaneously on their right foot.Therefore,pleurisy and inflammation of foot occurred to the rats.The Voatile Oil of Magnolia biondii Pamp.(VOMP) was given to the treatment rats before the injection of inflammagen.The results showed that VOMP can relieve the inflammation,and inhibit the production of inflammatory mediators,such as TNF,histamine,PGE_2 and the activity of PLA_2.These indicated that the anti-inflammatory effect of VOMP wasn′t relevant to the animals′ hypothalamus-adenohypophysis-adrenal axis.

关 键 词：望春花 抗炎 下丘脑-垂体-肾上腺轴 机理 炎症介质 角叉菜胶 PGE2 PLA2 挥发油 胸膜炎 试验组 对照 TNF 组织胺 相关酶 大鼠 注射 灌服 

分 类 号：S685.15[农业科学—观赏园艺] TQ658.41[农业科学—园艺学]