乙型肝炎随访肝活检肝内血管病变动态变化观察  

Dynamic changes of intrahepatic vascular diseases in follow-up biopsies of hepatitis B

作　　者：孙红霞[1] 杨凯[1] 

机构地区：[1]安徽省淮北市人民医院感染科,235000

出　　处：《淮海医药》2005年第3期173-175,共3页Journal of Huaihai Medicine

摘　　要：目的　研究肝内血管病变在乙型肝炎(HB)病程中的表现及意义。方法　对138例HB患者首、末2次肝活检标本用组织化学(组化)、免疫组织化学(免疫组化)染色及电镜技术进行了观察。结果　肝血管炎症、破坏、阻塞、增生及肝窦毛细血管化是HB组织学一大特点,其病变可引发肝血供障碍,导致肝细胞变性坏死、纤维化及肝硬变。经治疗多数肝血管病变是可逆的,首、末2次相比差异有显著性(P<0 .0 5 )。结论　在HB的病程中,致病源主要是HBV,有多种蛋白质参与其病理转化。肝内血管病变是影响HB肝组织学后果的关键因素。Objective To study the manifestation and significance of intra hepatic vascular diseases during hepatit is B(HB).Methods 138 cases of pati ents who had been performed biopsies at least two times were selected,and observ ed with histochemistry,immunohistochem istry and electron microscope.Results Intrahepatic vascular inflammory,des truction,obstruction,proliferation and h epatic sinusoidal capillarization are im portant histological characters in HB.Th e diseases can lead to disorder of hepat ic blood supply,which in turn may result in degeneration and necrosis of hepatoc y tes,fibrosis and cirrhosis.Many cases of the intrahepatic vascular diseases are reversible after treatment.There is sign ificant difference between the first and the last biopsies(P<0.05).Conclusi on During the course of HB,the source of the disease is HBV,and many proteins take part in the pathological conversio n.Intrahepatic vascular diseases are key factors influencing hepatic histologica l outcome of HB.

关 键 词：肝内血管病变 乙型肝炎 动态变化 肝窦毛细血管化 随访 免疫组织化学 肝活检标本 肝细胞变性 肝血管病变 电镜技术 免疫组化 血管炎症 血供障碍 病理转化 肝组织学 肝硬变 纤维化 显著性 HBV 致病源 蛋白质 病程 

分 类 号：R512.602[医药卫生—内科学] R512.62[医药卫生—临床医学]