氯化D,L-肉碱腈的制备和拆分研究  

Study on the Preparation and Resolution of D,L-Cyano-carnitine Chloride

作　　者：肖鉴谋[1] 孙曰圣[1] 张小林[1] 杨期勇[1] 

机构地区：[1]南昌大学化学工程系,江西南昌330029

出　　处：《化学世界》2005年第4期234-237,共4页Chemical World

摘　　要：对用氯化3 氯 2 羟丙基三甲胺(CHPTMA)制备氯化D,L 肉碱腈的工艺条件进行了研究,最佳的反应条件是:反应温度40～45℃,反应时间1.5h,物料CHPTMA与氰化钠的摩尔比为1∶1.05。在此条件下,产率为78.8%。研究了利用N 乙酰 L 谷氨酸为拆分试剂对氯化D,L 肉碱腈进行拆分,氯化L 肉碱腈的一次拆分光学纯度为92%,产率为37%;二次拆分光学纯度达95%。The preparation of D,L-cyano-carnitine chloride from 3-chloro-2-hydroxypropyl trime-thylamine chloride was studied. The best reaction conditions are:reaction temperature is 40～45℃; reaction time is 1.5 h; molar ratio of 3-chloro-2-hydroxypropyl trimethylamine chloride and sodium cyanide is 1∶1.05. Under the conditions, the yield of D,L-cyano-carnitine chloride is 78.8%. The separation of the enantiomers of D,L-cyano-carnitine chloride was also studied using N-acetyl-L-glutamic acid as the resolution agent. The enantiomer purity of L-cyano-carnitine chloride after the first resolution is 92% with 37% yield. The Enantiomer purity after the second resolution is 95%.

关 键 词：L-肉碱 氯化 制备 腈 光学纯度 L-谷氨酸 工艺条件 反应温度 反应条件 反应时间 拆分试剂 三甲胺 羟丙基 摩尔比 氰化钠 产率 物料 

分 类 号：TQ242.1[化学工程—有机化工] S816.7[农业科学—饲料科学]